業績
2024年

  1. Yonezawa H, Kokubu E, Kikuchi Y, Ishihara K. Complete genome sequence of Fusobacterium vincentii strain TDC100 isolated from an apical periodontitis lesion. Microbiol Resour Announc. 2024 13: e0119723. doi: 10.1128/mra.01197-23
  2. Shirai T, Satoh Y, Ishihara K. Antibacterial activity of mulberry extracts and purified fractions against oral pathogenic bacteria. J Oral Biosci. 2024 66: 439-46. doi: 10.1016/j.job.2023.12.009
  3. Numata Y, Kikuchi Y, Sato T, Okamoto-Shibayama K, Ando Y, Miyai-Murai Y, Kokubu, E, Ishihara, K.. Novel transcriptional regulator OxtR1 regulates potential ferrodoxin in response to oxygen stress in Treponema denticola. Anaerobe. 2024;87:102852. doi: 10.1016/j.anaerobe.2024.102852
  4. Ishizuka H, Ishihara K, Yonezawa H, Ishihara K, Muramatsu T. Inhibitory effect of bovine milk osteopontin on the initial attachment of Streptococcus mutans. JDS Communications. 2024. doi: 10.3168/jdsc.2024-0558
  5. Ando Y, Tsukasaki M, Huynh NC, Zang S, Yan M, Muro R, et al. The neutrophil-osteogenic cell axis promotes bone destruction in periodontitis. Int J Oral Sci. 2024 16:18. doi: 10.1038/s41368-023-00275-8

2023年

  1. Yamaguchi-Kuroda Y, Kikuchi Y, Kokubu E, Ishihara K. Porphyromonas gingivalis diffusible signaling molecules enhance Fusobacterium nucleatum biofilm formation via gene expression modulation. J Oral Microbiol. 2023 15: 2165001. doi: 10.1080/20002297.2023.2165001
  2. Miyai-Murai Y, Okamoto-Shibayama K, Sato T, Kikuchi Y, Kokubu E, Potempa J, et al. Localization and pathogenic role of the cysteine protease dentipain in Treponema denticola. Mol Oral Microbiol. 2023 38: 212-23. doi: 10.1111/omi.12406
2022年

  1. Kokubu E, Kikuchi Y, Okamoto-Shibayama K, Ishihara K. Effect of Treponema denticola infection on epithelial cells. Bull Tokyo Dent Coll. 2022 63:13-22.

2021年

  1. Shimogishi M, Watanabe T, Shibasaki M, Shiba T, Komatsu K, Nemoto T, Ishihara K, Nakano Y, Iwata T, Kasugai S, Nakagawa I. Patient-specific establishment of bacterial composition within the peri-implant microbiota during the earliest weeks after implant uncovering. J Periodontal Res. 2021 56: 964-71. doi: 10.1111/jre.12898
  2. Shiba T, Watanabe T, Komatsu K, Koyanagi T, Nemoto T, Ohsugi Y, Michi Y, Katagiri S, Takeuchi Y, Ishihara K, Iwata T. Non-surgical treatment for periodontitis and peri-implantitis: longitudinal clinical and bacteriological findings-A case report with a 7-year follow-up evaluation. SAGE Open Med Case Rep. 2021 9:1-8. doi: 10.1177/2050313X211029154
  3. Okamoto-Shibayama K, Yoshida A, Ishihara K. Inhibitory effect of resveratrol on Candida albicans biofilm formation. Bull Tokyo Dent Coll. 2021 62:1-6. doi: 10.2209/tdcpublication.2020-0023
  4. Okamoto-Shibayama K, Warita T, Kokubu E, Kita D, Kikuchi Y, Ishihara K. Role of hyalin-like protein in gliding and biofilm formation by Capnocytophaga ochracea. Bull Tokyo Dent Coll. 2021 62:89-98. doi: 10.2209/tdcpublication.2020-0051
  5. Nakane S, Imamura K, Hisanaga R, Ishihara K, Saito A. Systemic administration of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)-Ig abrogates alveolar bone resorption in induced periodontitis through inhibition of osteoclast differentiation and activation: An experimental investigation. J Periodontal Res. 2021 56: 972-81. doI: 10.1111/jre.12909
  6. Kokubu E, Kikuchi Y, Okamoto-Shibayama K, Nakamura S, Ishihara K. Crawling motility of Treponema denticola modulated by outer sheath protein. Microbiol Immunol. 2021 65: 551-8. doi: 10.1111/1348-0421.12940
  7. Kikuchi Y, Okamoto-Shibayama K, Kokubu E, Ishihara K. OxyR inactivation reduces the growth rate and oxidative stress defense in Capnocytophaga ochracea. Anaerobe. 2021 72: 102466. doi: 10.1016/j.anaerobe.2021.102466
  8. Kikuchi Y, Ishihara K. Characterization of the Treponema denticola virulence factor dentilisin. Methods Mol Biol. 2021 2210: 173-84. doi: 10.1007/978-1-0716-0939-2_17
  9. Izawa K, Okamoto-Shibayama K, Kita D, Tomita S, Saito A, Ishida T, Ohue M, Akiyama Y, Ishihara K. Izawa K, Okamoto-Shibayama K, Kita D, Tomita S, Saito A, Ishida T, et al. Taxonomic and gene category analyses of subgingival plaques from a group of Japanese individuals with and without periodontitis. Int J Mol Sci. 2021 22: 5298. doi: 10.3390/ijms22105298
  10. Akiyama, Y, Minabe M, Inada J, Nomura T, Takahashi S, Ishihara K, Kouno M. The oral microbial composition and diversity affect the clinical course of palmoplantar pustulosis patients after dental focal infection treatment. J Dermatol Sci. 2021 104 : 193-200. doi: 10.1016/j.jdermsci.2021.11.001

2020年

  1. Satoh Y, Ishihara K. Investigation of the antimicrobial activity of Bilberry (Vaccinium myrtillus L.) extract against periodontopathic bacteria. J Oral Biosci. 2020 62:169-74.
  2. Horiuchi A, Kokubu E, Warita T, Ishihara K. Synergistic biofilm formation by Parvimonas micra and Fusobacterium nucleatum. Anaerobe. 2020 62:102100. doi: 10.1016/j.anaerobe.2019.102100
  3. Arai Y, Kikuchi Y, Okamoto-Shibayama K, Kokubu E, Shintani S, Ishihara K. Investigation of the potential regulator proteins associated with the expression of major surface protein and dentilisin in Treponema denticola. J Oral Microbiol. 2020 12:1829404. doi: 10.1080/20002297.2020.1829404


  1. 2019年
  1. Kokubu E, Kinoshita E, Ishihara K. Inhibitory effects of lingonberry extracts on oral streptococcal biofilm formation and their bioactibity. Bull Tokyo Dent Coll 2019 60:1-9. doi: 10.2209/tdcpublication.2018-0007
  2. Kouno M, Akiyama Y, Minabe M, Iguchi N, Nomura T, Ishihara K, Takahashi S. Dysbiosis of oral microbiota in palmoplantar pustulosis patients. J Dermatol Sci 2019 93:67-69. doi: 10.1016/j.jdermsci.2018.12.003

2018年
  1. Harada R, Kokubu E, Kinoshita H, Yoshinari M, Ishihara K, Kawada, E, Takemoto S. Corrosion behavior of titanium in response to sulfides produced by Porphyromonas gingivalis. Dent Mater 2018 34: 183-191. doi: 10.1016/j.dental.2017.10.004
  2. Kokubu E, Inoue T, Ishihara K.Response of epithelial cells infected by Treponema denticola. Oral Dis 2018 24: 14-18. doi: 10.1111/odi.12794
  3. Ishihara K. New approach for studying mobile genes using metagenomic analysis. Oral Dis 2018 24: 494-496. doi: 10.1111/odi.12640
  4. Udagawa S, Katagiri S, MaekawaS, Takeuchi Y, Komazaki R, Ohtsu A, Sasaki N, Shiba T, Watanabe K, Ishihara K, Sato N, Miyasaka N, Izumi Y. Effect of Porphyromonas gingivalis infection in the placenta and umbilical cord in pregnant mice with low birth weight. Acta Odontol Scand 2018 76: 433-441. doi: 10.1007/s10388-018-0624-x
  5. Kikuchi Y, Kimizuka R, Kokubu E, Ishihara K. Treponema denticola induces epithelial barrier dysfunction in polarized epithelial cells. Bull Tokyo Dent Coll 2018 59:265-275. doi: 10.2209/tdcpublication.2017-0052
  6. Yoshikawa K, Kikuchi Y, Kokubu E, Imamura K, Saito A, Ishihara K. Identification of a specific domain of Porphyromonas gingivalis Hgp44 responsible for adhesion to Treponema denticola. Pathos Dis 2018 76: fty047. doi: 10.1093/femspd/fty047
  7. Tanno-Nakanishi M, Kikuchi Y, Kokubu E, Yamada S, Ishihara K. Treponema denticola transcriptional profiles in serum-restricted conditions. FEMS Microbiol Lett 2018 365: fny171. doi: 10.1093/femsle/fny171
  8. Asai T, Okamoto-Shibayama K, Kikuchi Y, Ishihara K. Characterization of a novel potential peptide import system in Treponema denticola. Microb Pathog 2018 123: 467-472. doi: 10.1016/j.micpath.2018.07.045

2017年
  1. Ota K, Kikuchi, Y, Imamura K, Kita D, Yoshikawa K, Saito A, Ishihara K. SigCH, an extracytoplasmic function sigma factor of Porphyromonas gingivalis regulates the expression of cdhR and hmuYR. Anaerobe 2017 43: 82-90. doi: 10.1016/j.anaerobe.2016.12.006
  2. Morita M, Iwasaki R, Sato Y, Kobayashi T, Watanabe R, Oike, T, Nakamura S, Keneko Y, Miyamoto K, Ishihara K, Iwakura Y, Ishii, K, Matsumoto M, Nakamura M, Kawana H, Nakagawa T, Miyamoto T. Elevation of pro-inflammatory cytokine levels following anti-resorptive drug treatment is required for osteonecrosis development in infectious osteomyelitis. Sci Rep 2017 7: 46322. doi: 10.1038/srep46322
  3. Fujise K, Kikuchi Y, Kokubu E, Okamoto-Shibayama K, Ishihara K. Effect of extracytoplasmic function sigma factors on autoaggregation, hemagglutination, and cell surface properties of Porphyromonas gingivalis. PLoS One 2017 12: e0185027 doi: 10.1371/journal.pone.0185027
  4. Okamoto-Shibayama K, Sekino J, Yoshikawa K. Saito A, Ishihara K. Antimicrobial susceptibility profiles of oral Treponema species. Anaerobe 2017 48: 242-248. doi: 10.1016/j.anaerobe.2017.10.005
  5. Okamoto-Shibayama K, Kikuchi Y, Kokubu E, Ishihara K. Possible involvement of surface antigen protein 2 in the morphological transition and biofilm formation of Candida albicans. Med Mycol. J. 2017 58:E139-E143. doi: 10.3314/mmj.17-00008.
  6. 石原和幸. Treponema denticolaの病原性因子. 日歯周誌 59: 144-151. doi: 10.2329/perio.59.144


2016年
  1. Imamura K, Kokubu E, Kita D, Ota K, Yoshikawa K, Ishihara K, Saito A, Role of mitogen-activated protein kinase pathways in migration of gingival epithelial cells in response to stimulation by cigarette smoke condensate and infection by Porphyromonas gingivalis. J Periodont Res 2015 51: 613-621. doi: 10.1111/jre.12341
  2. Hosohama-Saito K, Kokubu E, Okamoto-Shibayama K, Kita D, Kamakura A, Ishihara K. Involvement of luxS in biofilm formation by Capnocytophaga ochracea. ProS One 2016 11:e0147114. doi: 10.1371/journal.pone.0147114
  3. Kita D, Shibata S, Kikuchi Y, Kokubu E, Nakayama K, Saito A, Ishihara K. Involvement of the type IX secretion system in the gliding motility and biofilm formation of Capnocytophaga ochracea. Appl Environ Microbiol. 2016 82:1756-1766. doi: 10.1128/AEM.03452-15
  4. Inagaki S, Kimizuka R, Kokubu E, Saito A, Ishihara K. Treponema denticola invasion into human gingival epithelial cell. Microb Pathog 2016 94:104-111. doi: 10.1016/j.micpath.2016.01.010
  5. Narita M, Shibahara T, Takano N, Fujii R, Okuda K, Ishihara K. Antimicrobial susceptibility of microorganisms isolated from periapical periodontitis lesions. Bull Tokyo Dent Coll 57:133-42. doi: 10.2209/tdcpublication.2015-0018
  6. Tanaka-Kumazawa K, Kikuchi Y, Sano-Kokubun Y, Shintani S, Yakushiji M, Kuramitsu H K, Ishihara K. Characterization of a potential ABC-type bacteriocin exporter protein from Treponema denticola. BMC Oral Health 2016 17: 18. doi: 10.1186/s12903-016-0243-7
  7. Kadowaki T, Yukitake H, Naito M, Sato K, Kikuchi Y, Kondo Y, Shoji M, Nakayama K. A two-component system regulates gene expression of the type IX secretion component proteins via an ECF sigma factor. Sci Rep. 2016 6:23288. doi: 10.1038/srep23288


2015年
  1. Onozawa S, Kikuchi Y, Shibayama K, Kokubu E, Nakayama M, Inoue T, Nakano K, Shibata Y, Ohara N, Nakayama K, Ishihara K, Kawakami T, Hasegawa H. Role of extracytoplasmic function sigma factors inbiofilm formation of Porphyromonas gingivalis. BMC oral health 2015 15: 4
  2. Izumi S, Ryu M, Ueda T, Ishihara K, Sakurai K. Evaluation of application possibility of water containing organic acids for chemical denture cleaning for older adults. Geriatrics & Gerontology International 2015 16:300-306. doi: 10.1111/ggi.12467
  3. Ishii Y, Imamura K, Kikuchi Y, Miyagawa S, Hamada R, Sekino J, Sugito H, Ishihara K, Saito A. Point-of-care detection of Tannerella forsythia using an antigen-antibody assisted dielectrophoretic impedance measurement method. Micro Pathos 2015 82:37-42. doi: 10.1016/j.micpath.2015.03.017
  4. Takayama S, Hashimoto K, Kokubu E, Taniguchi M, Tajima K, Ochiai A, Saitoh E, Saito A, Ishihara K, Kato T. Inhibitory effects of a novel cationic dodecapeptide [CL(14-25)] derived from cyanate lyase of rice on endotoxic activities of LPSs from Escherichia coli and periodontopathic Aggregatibacter actinomycetemcomitans. Microb Pathog 2015 94:2-11. doi: 10.1016/j.micpath.2015.08.011
2014年
  1. Hagiwara M, Kokubu E, Sugiura S, Komatsu T, Tada H, Isoda R, Tanigawa N, Kato Y, Ishida N, Kobayashi K, Nakashima M, Ishihara K, Matsushita K. Vinculin and Rab5 complex is required [correction of requited]for uptake of Staphylococcus aureus and interleukin-6 expression. PLoS One 2014 9: e87373.
  2. Hirota K, Inagaki S, Hamada R, Ishihara, K, Miyake, Y. Evaluation of a rapid oral bacteria quantification system using dielectrophoresis and the impedance measurement. Biocontrol Sci 2014 19: 45-49.
  3. Okamoto-Shibayama K, Kikuchi Y, Kokubu E, Sato Y, Ishihara K. Csa2, a member of the Rbt5 protein family, is involved in the utilization of iron from human hemoglobin during Candida albicans hyphal growth. FEMS Yeast Res 2014 14: 674-677
  4. Imamura K, Kokubu E, Kita D, Oota K, Ishihara K, Saito A. Cigarette smoke condensate modulates migration of human gingival epithelial cells and their interactions with Porphyromonas gingivalis J Periodont Res DOI: 10.1111/jre.12222 in press
  5. Sano Y, Okamoto-Shibayama K, Tanaka K, Ito R, Shintani S, Yakushiji M, Ishihara K. Dentilisin involvement in coaggregation between Treponema denticola and Tannerella forsythia. Anaerobe 30:45-50
  6. Kokubu E, Kokubun K, Matsuzaka K, Kashiwagi K, Shiba K, Inoue T, Ishihara K, Yoshinari M. The effect of artificial recombinant bone morphogenetic protein 2 with titanium-binding peptide on a Ti graft in vivo. J Oral Tissue Engin 2014 12: 1-7
  7. Ao M, Miyauchi M, Inubushi T, Kitagawa M, Furusho H, Ando T, Ayuningtyas NF, Nagasaki A, Ishihara K, Tahara H, Kozai K, Takata T. Infection with Porphyromonas gingivalis Exacerbates Endothelial Injury in Obese Mice. PLoS One 2014 9:e110519.
2013年
  1. Yamamoto Y, Ishihara K, Muramatsu K, Wada Y, Kiwaki M, Kushiro A Okuda K. Expression of the Gingipain Antigen Hgp44 Domain of Porphyromonas gingivalis on the Surface of Lactococcus lactis. Bull Tokyo Dent Coll 2013 54: 233-241
  2. Koga T, Matsukubo T, Okuda K. Ishihara K. Effect of clinical factors on bacterial contamination of bone chips collected during implant surgery. Implant Dentistry 2013 22: 525-529.
2012 年
  1. Ohki T, Itabashi Y, Kohno T, Yoshizawa A, Nishikubo S, Watanabe S, Yamane G, Ishihara K. Detection of periodontal bacteria in thrombi of patients with acute myocardial infarction by polymerase chain reaction. Am Heart J; 2012 163: 164-167.
  2. Okuda T, Kokubu E, Kawana T, Saito A, Okuda K, Ishihara K. Synergy in biofilm formation between Fusobacterium nucleatum and Prevotella species. Anaerobe 2012 18:110-116.
  3. Okuda, T, Okuda, K, Kokubu, E, Kawana, T, Saito, A, Ishihara, K. Synergistic effect on biofilm formation between Fusobacterium nucleatum and Capnocytophaga ochracea. Anaerobe 2012 18:157-161.
  4. Aoki M, Takanashi K, Matsukubo T, Yajima, Y, Okuda K, Sato T,Ishihara K. Transmission of Periodontopathic Bacteria from Natural Teeth to Implants. Clin Implant Dent Relat Res 2012 14: 406-411.
  5. Yasui M, Ryu M, Sakurai K, Ishihara K. Colonization of oral cavity by periodontopathic bacteria in complete denture wearers. Gerodontology 2012 29: e494-e502
  6. Hosaka Y, Saito A, Maeda R, Fukaya C, Morikawa S, Makino A, Ishihara K, Nakagawa T. Antibacterial activity of povidone-iodine against an artificial biofilm of Porphyromonas gingivalis and Fusobacterium nucleatum. Arch Oral Biol 2012 57: 364-368
  7. Saito A, Kokubu E, Inagaki S, Imamura K, Kita D, Lamont R J, Ishihara K. Porphyromonas gingivalis entry into gingival epithelial cells modulated by Fusobacterium nucleatum is dependent on lipid rafts. Microb Pathog 2012 53: 234-242

  1. 2011年
  1. Kubota M, Tanno-Nakanishi M, Yamada S, Okuda K, Ishihara K. Effect of smoking on subgingival microflora of patients with periodontitis in Japan. BMC Oral Health 2011; 11: 1
  2. Saito, T, Inagaki, S, Sakurai K, Okuda K, Ishihara K. Exposure of P. gingivalis to noradrenaline reduces bacterial growth and elevates ArgX protease activity. Arch Oral Biol; 2011 56: 244-250
  3. Inagaki S, Saeki Y, Ishihara K. Funoran-containing xylitol gum and tablets inhibit adherence of oral streptococci. J Oral Biosci 2011; 53: 82-86
  4. Muramatsu K, Kokubu E, Shibahara T, Okuda K, Ishihara K. HGP44 induces protection against Porphyromonas gingivalis-induced alveolar bone loss in mice. Clin Vaccine Immunol; 2011 18: 888-891
  5. Yamada M, Ishihara K, Ogawa T, Sakurai K. The inhibition of infection by wound pathogens on scaffold in tissue-forming process using N-acetyl cysteine. Biomaterials; 2011 32: 8474-8485
  6. Sato R, Matsuzaka K, Kokubu E, Inoue T. Immediate loading after implant placement following tooth extraction up-regulates cellular activity in the dog mandible. Clin Oral Implants Res 2011 22:1372-1378

Book
  1. Ishihara, K., Inagaki, S., Saito, A. Chapter 44. Capnocytophaga, CRC press, Molecular Detection of Human Bacterial Pathogens, CRC press, Boca Raton, 2011
  2. Saito A., Inagaki S., Kokubu E, Kimizuka R, Ishihara K., Invasion of Host Cells by Porphyromonas gingivalis in Polymicrobial Infection, p. 257-271, In Yamamoto SL ed., Periodontal Disease: Symptoms, Treatment and Prevention, Nova Science Publishers, Hauppauge, 2011

2010年
  1. Ishihara, K, Wawrzonek, K, Shaw, LN, Inagaki, S, Miyamoto, M, Potempa, J. Dentipain, a Streptococcus-pyogenes-IdeS-protease homologue, is a novel virulence factor of Treponema denticola. Biol Chem 2010; 391: 1047–1055
  2. Ito R, Ishihara K, Shoji M, Nakayama K, Okuda K. Hemagglutinin/adhesin domains of Porphyromonas gingivalis play key roles in coaggregation with Treponema denticola. FEMS Immunol Med Microbiol 2010; 60: 251–260
  3. Abe S, Imaizumi M, Mikami Y, Wada Y, Tsuchiya S, Irie S, Suzuki S, Satomura K, Ishihara K, Honda MJ. Oral bacterial extracts facilitate early osteogenic/dentinogenic differentiation in human dental pulp–derived cells. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010; 109: 149-154
  4. Ryu, M, Ueda, T, Saito, T, Yasui, M, Ishihara, K, Sakurai, K. Oral environmental factors affecting number of microbes in saliva of complete denture wearers. J Oral Rehabil 2010; 37: 194-201
  5. Yamada, K, Yama, M, Takaku, Y, Kakizawa, T, Kimizuka, R, Okuda, K, Kato,T. Antimicrobial activity of super-oxidised water against oral microorganisms. Arch Oral Biol 2010; 55: 397-400
  6. Yamazaki-Kubota T, Miyamoto M, Sano Y, Kusumoto, M, Yonezu, T, Sugita, K, Okuda, K, Yakushiji, M, Ishihara, K. Analysis of matrix metalloproteinase (MMP-8 and MMP-2) activity in gingival crevicular fluid from children with Down’s syndrome. J Periodont Res 2010; 45: 170-176
  7. Saito, T, Ishihara, K, Ryu, M, Okuda, K, Sakurai, K. Fimbriae-associated genes are biofilm-forming factors in Aggregatibacter actinomycetemcomitnas strains. Bull Tokyo Dent Coll 2010; 51: 145-150
  8. Miura T, Iohara K, Kato T, Ishihara K, Yoshinari M. Basic peptide protamine exerts antimicrobial activity against periodontopathic bacteria. J Biomed Sci Eng 2010; 3: 1069-1072
  9. 穂坂康朗, 齋藤　淳, 石原和幸, 中川種昭. 歯周病関連細菌に対するsitafloxiacinの抗菌力について. 日歯周誌 2010; 52: 239-244
  10. Kenmotsu M, Matsuzaka K, Kokubu E, Azuma T, Inoue T. Analysis of side population cells derived from dental pulp tissue. Int Endod J 2010; 43: 1132-1142
  11. Yamawaki K, Matsuzaka K, Kokubu E, Inoue T. Effects of epidermal growth factor and/or nerve growth factor on Malassez's epithelial rest cells in vitro: expression of mRNA for osteopontin, bone morphogenetic protein 2 and vascular endothelial growth factor. J Periodontal Res 2010; 45: 421-427
Review
  1. Ishihara, K. Virulence factors of Treponema denticola. Periodontol 2000 2010; 54: 117-135

2009年
  1. Saito A, Inagaki S, Ishihara K. Differential ability of periodontopathic bacteria to modulate invasion of human gingival epithelial cells by Porphyromonas gingivalis. Microb Pathog 2009; 47: 329-333.
  2. Kotoku Y, Kato J, Akashi G, Hirai Y, Ishihara K. Bactericidal effect of a 405-nm diode laser on Porphyromonas gingivalis. Laser Phys Lett 2009; 6: 388-392.
  3. Kato T, Uzawa A, Ishihara K. Inhibitory effect of galectin-3 on the cytokine-inducing activity of periodontopathic Aggregatibacter actinomycetemcomitans endotoxin in splenocytes derived from mice. FEMS Immunol Med Microbiol 2009; 57: 40-45.
  4. Takayama S, Saitoh E, Kimizuka R, Yamada S, Kato T. Effect of eel galectin AJL-1 on periodontopathic bacterial biofilm formation and their lipopolysaccharide-mediated inflammatory cytokine induction. Int J Antimicrob Agents 2009; 34: 355-359.
  5. Ushida, N, Ishihara, K, Kobayashi, N, Matsukubo, T, Yakushiji, M, Okuda, K. Initial acquisition and transmission of Streptococcus mutans from Japanese mothers to children. Pediatric Dental Journal 2009; 19: 98-105.
  6. Kimizuka, R, Kato, T, Hashimoto, S, Yamanaka-Okada, A, Okuda, K, Ishihara, K. Congo red-binding protein in rough-phenotype Aggregatibacter actinomycetemcomitans is amyloid-like fiber. Bull Tokyo Dent Coll 2009; 50: 23-29.
  7. Fujii R, Saito Y, Tokura Y, Nakagawa K-I, Okuda K, Ishihara K. Characterization of bacterial flora in persistent apical periodontitis lesions. Oral Microbiol Immunol 2009; 24: 502-505.
  8. Honma K, Mishima E, Inagaki S. The OxyR homologue in Tannerella forsythia regulates expression of oxidative stress responses and biofilm formation. Microbiology 2009; 155: 1912-1922.


2008年
  1. Saito Y, Fujii R, Nakagawa KI, Kuramitsu HK, Okuda K, Ishihara K. Stimulation of Fusobacterium nucleatum biofilm formation by Porphyromonas gingivalis. Oral Microbiol Immunol 2008; 23: 1-6.
  2. Yamanaka-Okada A, Sato E, Kouchi T, Kimizuka R, Kato T, Okuda K. Inhibitory effect of cranberry polyphenol on cariogenic bacteria. Bull Tokyo Dent Coll 2008; 49: 107-112.
  3. Saito A, Inagaki S, Kimizuka R, Okuda, K, Hosaka, Y, Nakagawa, T, Ishihara, K. Fusobacterium nucleatum enhances invasion of human gingival epithelial and aortic endothelial cells by Porphyromonas gingivalis. FEMS Immunol Med Microbiol 2008; 54: 349-355.
  4. Makino A, Yamada S, Okuda K, Kato T. Nicotine involved in periodontal disease through influence on cytokine levels. FEMS Immunol Med Microbiol 2008; 52: 282-286.
  5. Kobayashi N, Ishihara K, Sugihara N, Kusumoto M, Yakushiji M, Okuda K. Colonization pattern of periodontal bacteria in Japanese children and their mothers. J Periodontal Res 2008; 43: 156-161.
  6. Ito T, Komiya-Ito A, Arataki T, Furuya, Y, Yajima, Y, Yamada, S, Okuda, K, Kato, T. Relationship between antimicrobial protein levels in whole saliva and periodontitis. J Periodontol 2008; 79: 316-322.
  7. Abe S, Ishihara K, Adachi M, Okuda K. Tongue-coating as risk indicator for aspiration pneumonia in edentate elderly. Arch Gerontol Geriatr 2008; 47: 267-275.
Review
  1. 石原和幸. 歯周病原性菌プロテアーゼと歯周炎. 日歯周誌 2008; 50: 3-10

2007年
  1. Miyachi K, Ishihara K, Kimizuka R, Okuda K. Arg-gingipain A DNA vaccine prevents alveolar bone loss in mice. J Dent Res 2007; 86: 446-450.
  2. Yamanaka A, Kouchi T, Kasai K, Kato T, Ishihara K, Okuda K. Inhibitory effect of cranberry polyphenol on biofilm formation and cysteine proteases of Porphyromonas gingivalis. J Periodontal Res 2007; 42: 589-592.
  3. Takahashi N, Ishihara K, Kato T, Okuda K. Susceptibility of Actinobacillus actinomycetemcomitans to six antibiotics decreases as biofilm matures. J Antimicrob Chemother 2007; 59: 59-65.
  4. Okuda T, Kimizuka R, Miyamoto M, Kato, T, Yamada, S, Okuda, K, Ishihara, K. Treponema denticola induces interleukin-8 and macrophage chemoattractant protein 1 production in human umbilical vein epithelial cells. Microbes Infect 2007; 9: 907-913.
  5. Adachi, M, Ishihara, K, Abe, S, Okuda, K. Professional oral health care by dental hygienists reduced respiratory infections in elderly persons requiring nursing care. Int J Dent Hyg 2007; 5: 69-74.

2006年
  1. Miyamoto M, Ishihara K, Okuda K. The Treponema denticola surface protease dentilisin degrades interleukin-1 ß (IL-1 ß), IL-6, and tumor necrosis factor alpha. Infect Immun 2006; 74: 2462-2467.
  2. Yasaki-Inagaki Y, Inagaki S, Yamada S, Okuda K, Ishihara K. Production of protective antibodies against Porphyromonas gingivalis strains by immunization with recombinant gingipain domains. FEMS Immunol Med Microbiol 2006; 47: 287-295.
  3. Yamazaki T, Miyamoto M, Yamada S, Okuda K, Ishihara K. Surface protease of Treponema denticola hydrolyzes C3 and influences function of polymorphonuclear leukocytes. Microbes Infect 2006; 8: 1758-1763.
  4. Takahashi N, Ishihara K, Kimizuka R, Okuda K, Kato T. The effects of tetracycline, minocycline, doxycycline and ofloxacin on Prevotella intermedia biofilm. Oral Microbiol Immunol 2006; 21: 366-371.
  5. Ohazama J, Motegi E, Nomura M, et al. Oral flora in independent over 80-year-olds with more than 20 teeth. Bull Tokyo Dent Coll 2006; 47: 1-4.
  6. Kato T, Kimizuka R, Okuda K. Changes of immunoresponse in BALB/c mice neonatally treated with periodontopathic bacterial endotoxin. FEMS Immunol Med Microbiol 2006; 47: 420-424.
  7. Kato T, Kaneko S, Kimizuka R, Okuda K. Periodontopathic bacterial endotoxin-induced tumor necrosis factor alpha production was inhibited by exercise in mice. FEMS Immunol Med Microbiol 2006; 47: 262-266.
  8. Abe S, Ishihara K, Adachi M, Sasaki H, Tanaka K, Okuda K. Professional oral care reduces influenza infection in elderly. Arch Gerontol Geriatr 2006; 43: 157-164.
  9. Abe S, Ishihara K, Adachi M, Okuda K. Oral hygiene evaluation for effective oral care in preventing pneumonia in dentate elderly. Arch Gerontol Geriatr 2006; 43: 53-64.
  10. Komiya-Ito, A, Ito, T, Yamanaka, A, Yamada, S, Okuda, K, Kato, T. N-Tetradecanoyl homoserine lactone, signaling compound for quorum sensing, inhibits Porphyromonas gingivalis growth. Res J Microbiol 2006; 1: 353-359.
  11. Yoshinari M, Kato T, Matsuzaka K, et al. Adsorption behavior of antimicrobial peptide histatin 5 on PMMA. J Biomed Mater Res B Appl Biomater 2006; 77: 47-54.

2005年
  1. Yonezawa H, Kato T, Kuramitsu HK, Okuda K, Ishihara K. Immunization by Arg-gingipain A DNA vaccine protects mice against an invasive Porphyromonas gingivalis infection through regulation of interferon-gamma production. Oral Microbiol Immunol 2005; 20: 259-266.
  2. Sasaki N, Okuda K, Kato T, et al. Salivary bisphenol-A levels detected by ELISA after restoration with composite resin. J Mater Sci Mater Med 2005; 16: 297-300.
  3. Okuda K, Kimizuka R, Abe S, Kato T, Ishihara K. Involvement of periodontopathic anaerobes in aspiration pneumonia. J Periodontol 2005; 76: 2154-2160.
  4. Miura T, Ishihara K, Kato T, Kimizuka, R, Miyabe, H, Ando, T, Uchiyama, T, Okuda, K. Detection of heat shock proteins but not superantigen by isolated oral bacteria from patients with Behcet's disease. Oral Microbiol Immunol 2005; 20: 167-171.
  5. Ito T, Komiya-Ito A, Okuda K, et al. Murine monoclonal antibody which can distinguish cystatins SA1 and SA2. Mol Immunol 2005; 42: 1259-1263.

2004年
  1. Ishihara K, Kuramitsu HK, Okuda K. A 43-kDa protein of Treponema denticola is essential for dentilisin activity. FEMS Microbiol Lett 2004; 232: 181-188.
  2. Yamanaka A, Kimizuka R, Kato T, Okuda K. Inhibitory effects of cranberry juice on attachment of oral streptococci and biofilm formation. Oral Microbiol Immunol 2004; 19: 150-154.
  3. Takarada K, Kimizuka R, Takahashi N, Honma K, Okuda K, Kato T. A comparison of the antibacterial efficacies of essential oils against oral pathogens. Oral Microbiol Immunol 2004; 19: 61-64.
  4. Takanashi K, Kishi M, Okuda K, Ishihara K. Colonization by Porphyromonas gingivalis and Prevotella intermedia from teeth to osseointegrated implant regions. Bull Tokyo Dent Coll 2004; 45: 77-85.
  5. Okuda K, Kato T, Ishihara K. Involvement of periodontopathic biofilm in vascular diseases. Oral Dis 2004; 10: 5-12.
  6. Miyabe H, Ishihara K, Kigure T, Okuda K. Anti-phagocytic role of surface fibrous structure of an invasive Porphyromonas gingivalis strain. Bull Tokyo Dent Coll 2004; 45: 47-57.
  7. Kato T, Ito T, Imatani T, Minaguchi K, Saitoh E, Okuda K. Cystatin SA, a cysteine proteinase inhibitor, induces interferon-gamma expression in CD4-positive T cells. Biol Chem 2004; 385: 419-422.
  8. Ishihara K, Nabuchi A, Ito R, Miyachi K, Kuramitsu HK, Okuda K. Correlation between detection rates of periodontopathic bacterial DNA in coronary stenotic artery plaque [corrected] and in dental plaque samples. J Clin Microbiol 2004; 42: 1313-1315.
  9. Imatani T, Kato T, Okuda K, Yamashita Y. Histatin 5 inhibits apoptosis in human gingival fibroblasts induced by Porphyromonas gingivalis cell-surface polysaccharide. Eur J Med Res 2004; 9: 528-532.

2003年
  1. Okuda K, Kimizuka R, Katakura A, Nakagawa T, Ishihara K. Ecological and immunopathological implications of oral bacteria in Helicobacter pylori-infected disease. J Periodontol 2003; 74: 123-128.
  2. Washizu M, Ishihara K, Honma K, Okuda K. Effects of a mixed infection with Porphyromonas gingivalis and Treponema denticola on abscess formation and immune responses in mice. Bull Tokyo Dent Coll 2003; 44: 141-147.
  3. Okuda M, Kaneko Y, Ichinohe T, Ishihara K, Okuda K. Reduction of potential respiratory pathogens by oral hygienic treatment in patients undergoing endotracheal anesthesia. J Anesth 2003; 17: 84-91.
  4. Kosugi M, Ishihara K, Okuda K. Implication of responses to bacterial heat shock proteins, chronic microbial infections, and dental metal allergy in patients with pustulosis palmaris et plantaris. Bull Tokyo Dent Coll 2003; 44: 149-158.
  5. Kimizuka R, Kato T, Ishihara K, Okuda K. Mixed infections with Porphyromonas gingivalis and Treponema denticola cause excessive inflammatory responses in a mouse pneumonia model compared with monoinfections. Microbes Infect 2003; 5: 1357-1362.
  6. Inagaki S, Ishihara K, Yasaki Y, Yamada S, Okuda K. Antibody responses of periodontitis patients to gingipains of Porphyromonas gingivalis. J Periodontol 2003; 74: 1432-1439.
  7. Ihara H, Miura T, Kato T, Ishihara, K, Nakagawa, T, Okuda, K. Detection of Campylobacter rectus in periodontitis sites by monoclonal antibodies. J Periodontal Res 2003; 38: 64-72.
  8. Eguchi J, Ishihara K, Watanabe A, Fukumoto Y, Okuda K. PCR method is essential for detecting Mycobacterium tuberculosis in oral cavity samples. Oral Microbiol Immunol 2003; 18: 156-159.
  9. Asano H, Ishihara K, Nakagawa T, Yamada S, Okuda K. Relationship between transmission of Porphyromonas gingivalis and fimA type in spouses. J Periodontol 2003; 74: 1355-1360.
  10. Nakagawa, T, Saito, A, Hosaka, Y, Ishihara, K. Gingipains as candidate antigens for Porphyromonas gingivalis vaccine. Keio J Med 2003; 52: 158-162.

2002年
  1. Adachi, M, Ishihara, K, Abe, S, Okuda, K, Ishikawa, T. Effect of professional oral health care on the elderly living in nursing homes. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002; 94: 191-195.
  2. Sumida S, Ishihara K, Kishi M, Okuda K. Transmission of periodontal disease-associated bacteria from teeth to osseointegrated implant regions. Int J Oral Maxillofac Implants 2002; 17: 696-702.
  3. Kato T, Imatani T, Minaguchi K, Saitoh E, Okuda K. Salivary cystatins induce interleukin-6 expression via cell surface molecules in human gingival fibroblasts. Mol Immunol 2002; 39: 423-430.
  4. Chattin-Kacouris BR, Ishihara K, Miura T, Okuda, K, Ikeda, M, Ishikawa, T, Rowland, R. Heat shock protein of Mycoplasma salivarium and Mycoplasma orale strains isolated from HIV-seropositive patients. Bull Tokyo Dent Coll 2002; 43: 231-236.

2001年
  1. Yonezawa H, Ishihara K, Okuda K. Arg-gingipain a DNA vaccine induces protective immunity against infection by Porphyromonas gingivalis in a murine model. Infect Immun 2001; 69: 2858-2864.
  2. Okuda K, Ishihara K, Nakagawa T, Hirayama A, Inayama Y. Detection of Treponema denticola in atherosclerotic lesions. J Clin Microbiol 2001; 39: 1114-1117.
  3. Kato T, Okuda K. Actinobacillus actinomycetemcomitans possesses an antigen binding to anti-human IL-10 antibody. FEMS Microbiol Lett 2001; 204: 293-297.
  4. Ishihara K, Miura T, Ebihara Y, Hirayama T, Kamiya S, Okuda K. Shared antigenicity between Helicobacter pylori and periodontopathic Campylobacter rectus strains. FEMS Microbiol Lett 2001; 197: 23-27.
  5. Imatani T, Kato T, Okuda K. Production of inflammatory cytokines by human gingival fibroblasts stimulated by cell-surface preparations of Porphyromonas gingivalis. Oral Microbiol Immunol 2001; 16: 65-72.
  6. Ikenoya H, Ishihara K, Okuda K. Cloning and characterization of a gene encoding an immunosuppressive factor from Actinobacillus actinomycetemcomitans. Bull Tokyo Dent Coll 2001; 42: 65-71.
  7. Hirose M, Ishihara K, Saito A, Nakagawa T, Yamada S, Okuda K. Expression of cytokines and inducible nitric oxide synthase in inflamed gingival tissue. J Periodontol 2001; 72: 590-597.
  8. Abe S, Ishihara K, Okuda K. Prevalence of potential respiratory pathogens in the mouths of elderly patients and effects of professional oral care. Arch Gerontol Geriatr 2001; 32: 45-55.
  9. Yoshinari M, Oda Y, Kato T, Okuda K. Influence of surface modifications to titanium on antibacterial activity in vitro. Biomaterials 2001; 22: 2043-2048.