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研究Research

主な論文

2019

Aoki H, Seshima F, Saito A.
Periodontal regenerative therapy using enamel matrix derivative in patient with chronic periodontitis: a 3-year 6-month follow-up report. Bull Tokyo Dent Coll (in press)

Saito A, Bizenjima T, Takeuchi T, Suzuki E, Sato M, Yoshikawa K, Kitamura Y, Matsugami D, Aoki H, Kita D, Imamura K, Irokawa D, Seshima F, Tomita S.
Treatment of intrabony periodontal defects using rhFGF-2 in combination with deproteinized bovine bone mineral or rhFGF-2 alone: A 6-month randomized controlled trial. J Clin Periodontol 46:332-341, 2019 (Open access)

Seshima F, Kigure T, Saito A.
Periodontal regenerative therapy using enamel matrix derivative for treatment of generalized severe chronic periodontitis: A 2-year case report. Bull Tokyo Dent Coll 60:97-104, 2019.

Bizenjima T, Osuka Y, Tomita S, Saito A.
Periodontal regenerative therapy with enamel matrix derivative in patient with chronic periodontitis: A 3.5-year follow-up report. Bull Tokyo Dentl Coll 60:131-138, 2019.

2018

Yoshikawa K, Kikuchi Y, Kokubu E, Imamura K, Saito A, Ishihara K.
Identification of a specific domain of Porphyromonas gingivalis Hgp44 responsible for adhesion to Treponema denticola.
Pathog Dis 76:1-8, 2018

Inoko M, Rubin S, Ono Y, Saito A.
Releasing incisions using Upward-Motion Scissors Technique for flap mobilization for guided bone regeneration or periodontal surgery: Technical introduction and a case report.
Int J Periodontics Restorative Dent 38:503-507, 2018 (doi: 10.11607/prd.3205).

Kita D, Kinumatsu T, Yokomizo A, Tanaka M, Egawa M, Makino-Oi A, Tomita S, Saito A.
Clinical effect of a dentifrice containing three kinds of bactericidal ingredients on periodontal disease: a pilot study in patients undergoing supportive periodontal therapy.
BMC Res Notes 11:116, 2018.

Hisanaga Y, Suzuki E, Aoki H, Sato M, Saito A, Saito A, Azuma T. Effect of the combined use of enamel matrix derivative and atelocollagen sponge scaffold on osteoblastic differentiation of mouse induced pluripotent stem cells in vitro.
J Periodontal Res 53:240-249, 2018.


2017

Nomura et al
Site-level progression of periodontal disease during a follow-up period
PlosOne 12:e0188670, 2017

Tomita S, Saito A.
Periodontal abscess: a review and the role of antimicrobial therapy.

Curr Oral Health Rep 4:294-300, 2017

Okamoto-Shibayama K, Sekino J, Yoshikawa K, Saito A, IshiharaK.
Antimicrobial sussceptibility profiles of oral Treponema species.
Anaerobe 48:242-248, 2017.

Seshima F, Aoki H, Takeuchi T, Suzuki E, Irokawa D, Makino-Oi A, Sugito H, Tomita S, Saito A.
Periodontal regenerative therapy with enamel matrix derivative in the treatment of intrabony defects: a prospective two-year study.
BMC Research Notes 10:256, 2017


Irokawa D, Okubo N, Nikaido M, Shimizu H, Konobu H, Matsui T, Fujita T, Goto H, Takeuchi T, Ishii Y, Saito A.

Periodontal regenerative therapy of intrabony defects using deproteinized bovine bone mineral in combination with collagen barrier membrane: A multicenter prospective case-series study.
Int J Periodontics Restorative Dent 37:393-401, 2017.

Ogata Y, et al.
Prevalence and risk factors for peri-implant diseases in Japanese adult dental patients.
J Oral Sci 59:1-11, 2017.

Irokawa D, Takeuchi T, Noda K, Goto H, Egawa M, Tomita S, Sugito H, Nikaido M, Saito A.
Clinical outcome of periodontal regenerative therapy using collagen membrane and deproteinized bovine bone mineral: a 2.5-year follow-up study. BMC Research Notes. 2017;10:102.

Kakuta E, Nomura Y, Morozumi T, Nakagawa T, Nakamura T, Noguchi K, et al. Assessing the progression of chronic periodontitis using subgingival pathogen levels: a 24-month prospective multicenter cohort study. BMC Oral Health. 2017;17:46.

Ota K, Kikuchi Y, Imamura K, Kita D, Yoshikawa K, Saito A, Ishihara K.
SigCH, an extracytoplasmic function sigma factor of Porphyromonas gingivalis regulates the expression of cdhR and hmuYR. Anaerobe 43:82-90, 2017

2016

Morozumi T, Nakagawa T, Nomura Y, Sugaya T, Kawanami M, Suzuki F, Takahashi K, Abe Y, Sato S, Makino-Oi A, Saito A, et al.
Salivary pathogen and serum antibody to assess the progression of chronic periodontitis: a 24-mo prospective multicenter cohort study. J Periodontal Res 51:768-778, 2016.

Nakayama Y, Ogata Y, Hiromatsu Y, Imamura K, Suzuki E, Saito A, Shirakawa S, Nagano T, Gomi K, Morozumi T, Watanabe K, Akiishi K, Yoshie H.
Clinical usefulness of novel immunochromatographic detection device for Porphyromonas gingivalis in evaluating effects of scaling and root planing and local antimicrobial therapy. J Periodontol 87:1238–47, 2016 .


Yoshikawa K, Sekino J, Imamura K, Ota K, Kita D, Saito A.
In vitro effect of mouthrinse containing essential oils on proliferation and migration of gingival epithelial cells. Phytother Res 30:1113-1118, 2016.

Takayama S, Hashimoto K, Kokubu E, et al.
Inhibitory effects of a novel cationic dodecapeptide [CL(14-25)] derived from cyanate lyase of rice on endotoxic activities of LPSs from Escherichia coli and periodontopathic Aggregatibactor actinomycetemcomitans. Microbial Pathogenesis 94:2-11, 2016


Imamura K, Kokubu E, Kita D, Ota K, Yoshikawa K, Ishihara K, Saito A.
Role of mitogen-activated protein kinase pathways in migration of gingival epithelial cells in response to stimulation by cigarette smoke condensate and infection by Porphyromonas gingivalis. J Periodontal Res 51:613-621, 2016.

Bizenjima T, Takeuchi T, Seshima F, Saito A.
Effect of poly (lactide-co-glycolide) (PLGA)-coated beta-tricalcium phosphate on the healing of rat calvarial bone defects: a comparative study with pure-phase beta-tricalcium phosphate. Clin Oral Impl Res 27:1360-1367, 2016.

Kita D, Shibata S, Kikuchi Y, Kokubu E, Nakayama K, Saito A, Ishihara K.
Involvement of the type IX secretion system in Capnocytophaga ochracea gliding motility and biofilm formation. Appl Environ Microbiol 82:1756-1766, 2016.


Inagaki S, Kimizuka R, Kokubu E, Saito A, Ishihara K.
Treponema denticola
invasion into human gingival epithelial cells. Microbial Pathogenesis 94:104-111, 2016.

Takeuchi T, Bizenjima T, Ishii Y, Imamura K, Suzuki E, Seshima F, et al.
Enhanced healing of surgical periodontal defects in rats following application of a self-assembling peptide nanofibre hydrogel. J Clin Periodontol 43:279-288, 2016.

Makino-Oi A, Isii Y, Hoshino T, Okubo N, Sugito H, Hosaka Y, Fukaya C, Nakagawa T, Saito A.
Effect of periodontal surgery on oral health-related quality of life in patients who have completed initial periodontal therapy.
J Periodontal Res 51:212-220, 2016.

2015

Takayama S, Kato T, Imamura K, Kita D, Ota K, Suzuki E, Sugito H, Saitoh E, Taniguchi M, Saito A.
Effect of a mouthrinse containing rice peptide CL(14-25) on early dental plaque regrowth: a randomized crossover pilot study.

BMC Research Notes 8:531,2015.


Imamura K, Takayama S, Saito A, Inoue E, Nakayama Y, Ogata Y, et al.
Evaluation of a novel immunochromatographic device for rapid and accurate clinical detection of Porphyromonas gingivalis in subgingival plaque.
Journal of Microbiological Methods 117:4-10,2015.

Ishii Y, Imamura K, Kikuchi Y, Miyagawa S, Hamada R, Sekino J, Sugito H, Ishihara K, Saito A.
Point-of-care detection of Tannerella forsythia using an antigen-antobody assisted dielectrohpretic impedance measurement method.
Microb Pathog 82:37-42, 2015

Bizenjima T, Seshima F, Ishizuka Y, Takeuchi T, Kinumatsu T, Saito A. Fibroblast growth factor-2 promotes healing of surgically created periodontal defects in rats with early, streptozotocin-induced diabetes via increasing cell proliferation and regulating angiogenesis. J Clin Periodontol 42:62-71, 2015.


Tomita S, Kasai S, Imamura K, Ihara Y, Kita D, Ota K, Sekino J, Nakagawa T, Saito A. Changes in antimicrobial susceptibility profile and prevalence of quinolone low-sensitive strains in subgingival plaque from acute periodontal lesions after systemic administration of sitafloxacin. Microb Pathog 79:41–46, 2015
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Nishina M, Hoshino T, Murai K, Miyata K, Ishii Y, Saito A.
Effect of collaborative intervention by medical and dental professhionals on adherence to smoking abstinence.
Bull Tokyo Dent Coll 56:57-61, 2015
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Imamura K, Kokubu E, Kita D, Ota K, Ishihara K, Saito A.
Cigarette smoke condensate modulates migration of human gingival epithelial cells and their interactions with Porphyromonas gingivalis. J Periodontal Res 50:411-421, 2015.

2014

Suzuki E, Ochiai-Shino H, Aoki H, Onodera S, Saito A, Saito A, Azuma T.
Akt activation is required for TGF-β1-induced osteoblast differentiation of MC3T3-E1 pre-osteoblasts.
PLoS ONE. 9(12):e112566, 2014.


Tomita S, Kasai S, Ihara Y, Imamura K, Kita D, Ota K, Kinumatsu T, Nakagawa T, Saito A. Effects of systemic administration of sitafloxacin on subgingival microflora and antimicrobial susceptibility profile in acute periodontal lesions. Microbial Pathogenesis
71-72:1-7, 2014.

Ishizuka Y, Shibukawa Y, Nagayama M, Decker R, Kinumatsu T, Saito A, Pacifici M, Koyama E.
TMJ Degeneration in SAMP8 Mice is accompanied by deranged Ihh signaling. J Dent Res 93:281-287, 2014.

2013

Komiya-Ito A, Ota M, Fujimoto Y, Tsunoda M, Saito A. Longitudial supportive periodontal therapy for severe chronic periodontitis with furcation involvements: a 12-year follow-up report. Bull Tokyo Dent Coll 54:243-250, 2013

Tomita S, Komiya-Ito A, Imamura K, Daichi K, Ota K, Takayama S, Makino-Oi A, Kinumatsu T, Ota M, Saito A. Prevalence of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis and Tannerella forsythia in Japanese patients with generalized chronic and aggressive periodontitis. Microbial Pathogenesis 61-62:11-15, 2013. doi:10.1016/j.micpath.2013.04.006.

Ota M, Seshima F, Okubo N, Kinumatsu T, Tomita S, Okubo T, Saito A.
A collaborative approach to care for patients with periodontitis and diabetes. Bull Tokyo Dental Coll 54:51-57, 2013

Ishii Y, Fujita T, Okubo N, Ota M, Yamada S, Saito A. Effect of basic fibroblast growth factor (FGF-2) in combination with beta tricalcium phosphate on root coverage in dogs. Acta Odontologica Scandinavica 71:325-332, 2013


Egawa M, Miura T, Kato T, Saito A, Yoshinari M. In vitro adherence of periodontopathic bacteria to zirconia and titanium surfaces. Dent Material J 32:101-106, 2013.

Okubo N, Fujita T, Ishii Y, Ota M, Shibukawa Y, Yamada S. Coverage of gingival recession defects using acellular dermal matrix allograft with or without beta-tricalcium phosphate. Journal of Biomaterials Applications 27:627-637, 2013

2012

Saito A, Kokubu E, Inagaki S, Imamura K, Kita D, Lamont RJ, Ishihara K.
Porphyromonas gingivalis entry into gingival epithelial cells modulated by Fusobacterium nucleatum is dependent on lipid rafts. Microb Pathog 53:234-242, 2012

Hayakawa H, Fujinami K, Ida A, Furusawa M, Nikaido M, Yamashita S, Saito A. Clinical outcome of surgical periodontal therapy: a short-term retrospective study. Bulletin of Tokyo Dental College 53: 189-195, 2012

Takanashi T, Fujinami K, Matsuzaki M, Sekine H, Saito A.Treatment of generalized aggressive periodontitis with enamel matrix derivative and implant prosthesis: a case report.Clinical Advances in Periodontics 2:187-194, 2012


Noda K, Seshima F, Okubo N, Ishii Y, Ota M, Yamada S, Saito A. Effect of platelet-derived growth factor-BB on root resorption after reimplantation of partially denuded tooth in dog. Dental Traumatology 2012; 28: 217-225

Okuda T, Okuda K, Kokubu E, Kawana T, Saito A, Ishihara K.Synergistic effect on biofilm formation between Fusobacterium nucleatum and Capnocytophaga ochracea. Anaerobe 18:157-161, 2012.

Shiratani S, Ota M, Fujita T, Seshima F, Yamada S, Saito A.Effect of basic fibroblast growth factor on root resorption after delayed autotransplantation of tooth in dogs.Oral Surg Oral Med Oral Pathol Oral Radiol 114:e14-e21, 2012

Okuda T, Kokubu E, Kawana T, Saito A, Okuda K, Ishihara K. Synergy in biofilm formation between Fusobacterium nucleatum and Prevotella species. Anaerobe 18:110-116, 2012

Hosaka, Y., Saito, A., Maeda R, Fukaya C, Morikawa S, Makino A, Ishihara K, Nakagawa T. Antibacterial activity of povidone-iodine against an artificial biofilm of Porphyromonas gingivalis and Fusobacterium nucleatum. Archives of Oral Biology 57:364-368, 2012.

2011

Saito A, Ota K, Hosaka Y, Akamatsu M, Hayakawa H, Fukaya C, Ida A, Fujinami K, Sugito H, Nakagawa T.Potential impact of surgical periodontal therapy on oral health-related quality of life in patients with periodontitis: a pilot study. Journal of Clinical Periodontology, 38:1115-1121, 2011.

Sugito H, Shibukawa Y, Kinumatsu T, Yasuda T, Nagayama M, Yamada S, Minugh-Purvis N, Pacifici M, Koyama E. Ihh signaling regulates mandibular symphysis development and growth. J Dent Res 90:625-631, 2011

Kinumatsu T, Shibukawa Y, Yasuda T, Nagayama M, Yamada S, Serra R, Pacifici M, Koyama E. TMJ development and growth require primary cilia function. J Dent Res 90:988-994, 2011


Fujita T, Yamamoto S, Ota M, Shibukawa Y, Yamada S. Coverage of gingival recession defects using guided tissue regeneration with and without adjunctive enamel matrix derivative in a dog model. Int J Periodontics Restorative Dent 31:247-253, 2011

Fujinami K, Hayakawa H, Ota K, Ida A, Nikaido M, Makiishi T, Saito A. Two-year follow-up of treatment of intrabony periodontal defect with enamel matrix derivative. Bull Tokyo Dent Coll 52, 215-221, 2011

Hayakawa H, Ota K, Ida A, Fujinami K, Furusawa M, Makiishi T, Nikaiko M, Ichinohe T, Saito A.Surgical periodontal therapy at Tokyo Dental College Suidobashi Hospital: A statistical profile in 2010-2011.Bull Tokyo Dent Coll 52, 223-228, 2011

Saito, A., Inagaki, K., Kokubu, E., Kimizuka, R., and Ishihara, K. (分担執筆). Invasion of host cells by Porphyromonas gingivalis in polymicrobial infection. In Periodontal Disease: Symptoms, Treatment and Prevention (Yamamoto S eds). Nova Science Publishers, Hauppauge, NY, 2011 (pp, 257-271, ISBN: 978-1-61761-739-3)

Ishihara, K., Saito, A., and Inagaki, K. (分担執筆) Capnocytophaga. In Molecular detection of human bacterial pathogens (Liu D eds), CRC Press, Boca Raton, 2011 (ISBN:  9781439812389)

Saito, A. and Fujinami, K.Introduction of formal debate into a postgraduate specialty track education programme in periodontics in Japan. European Journal of Dental Education, 15: 58-62, 2011





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