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活動状況・業績:2020年度

【タブモジュール】活動状況・業績

2017-2021年度活動報告書
総括報告(2017年度-2021年度)(本文)
総括報告(2017年度-2021年度)(資料)



若手サイエンスアカデミー : 基礎臨床融合カンファレンス

1.研究発表
【目的】本学で行われている研究内容の相互理解を深め、研究の発展および共同研究の提案に繋げることにより、研究活動をさらに活性化することを目指します。
発表日 氏名 講座 発表課題名
2020年9月23日
(WEB開催)
佐藤 涼一 衛生学講座 歯磨剤フッ化物有効利用のための 新規ブラッシング法 (PTD法) 開発
2.論文紹介
【目的】様々な研究分野の論文紹介を通して世の中の研究の流れ、手法および論文のまとめ方を学ぶことを目的とします。専門もしくはそれ以外の研究領域の知識を広げて現状を把握することにより、論文および研究費申請書作成の向上に繋げます。
発表日 紹介論文
2020年4月1日
(WEB開催)
Mx1+aSMA+骨膜幹細胞の固定
原題:Identification of Functionally Distinct Mx1+αSMA+ Periosteal Skeletal Stem Cells
雑誌:Cell Stem Cell 25(6):784, 2019
2020年6月10日
(WEB開催)
管腔臓器の長さと太さが決まる仕組みの解明
原題:Synchronized mesenchymal cell polarization and differentiation shape the formation of the murine trachea and esophagus
雑誌:Nat Commun 9(1):2816, 2018
2020年6月24日
(WEB開催)
歯周病の骨欠損における炎症性サイトカインIL-36 γの関与
原題: IL-36γ is a pivotal inflammatory player in periodontitis-associated bone loss
​雑誌: Scientific Reports 9: 19257, 2019
2020年7月8日
(WEB開催)
内皮細胞由来のクロストークは歯髄幹細胞の自己複製を調節する
原題:Endothelial-Initiated Crosstalk Regulates Dental Pulp Stem Cell Self-Renewal
雑誌:J Dent Res doi:10.1177/0022034520925417, 2020
2020年7月22日
(WEB開催)

PAEKグループ(PEEKおよびPEKK)のosseointegration向上のための表面処理
原題:Comparison of osteointegration property between PEKK and PEEK: Effects of surface structure and chemistry
雑誌:Biomaterials 170:116-126., 2018

2020年7月29日
(WEB開催)
乳児の口腔内細菌叢形成に母乳が果たしている役割
原題:​Microbiota of human precolostrum and its potential role as a source of bacteria to the infant mouth
雑誌:Scientific Reports 9(1):8435, 2019
2020年8月26日
​(WEB開催)

Wntを介した骨髄間質細胞の形質転換は骨再生を調節する​
原題: A Wnt-mediated transformation of the bone marrow stromal cell identity orchestrates skeletal regeneration
雑誌:Nat Commun 11(1):332, 2020 

2020年9月9日
(WEB開催)

臓器(マクロ)レベルのmechanoadapatationは、局所ひずみに必ずしも影響を受けるわけではない
原題: Lasting organ-level bone mechanoadaptation is unrelated to local strain
雑誌:Sci Adv 6: eaax8301, 2020

2020年10月7日
(WEB開催)
脂肪代謝がSOX9を介して軟骨と骨の分化スイッチを決定する
原題:Lipid availability determines fate of skeletal progenitor cells via SOX9
​雑誌:Nature 579(7797):111-117, 2020
2020年10月21日
(WEB開催)
レプチン受容体陽性細胞は歯槽骨における骨再生に寄与する
​原題:LepR-Expressing Stem Cells Are Essential for Alveolar Bone Regeneration
​雑誌:J Dent Res 99 (11): 1279, 2020
2020年11月4日
(WEB開催)
Gli1陽性歯根膜幹細胞は骨細胞と咬合力により制御される
原題:Gli1+ Periodontium Stem Cells Are Regulated by Osteocytes and Occlusal Force
​雑誌:Dev Cell 54(5):639, 2020
2020年11月18日
(WEB開催)
骨細胞のネクローシスはmacrophage-inducible C-type lectin (Mincle)を介して破骨細胞依存的な骨欠損を誘導する
原題:Osteocyte necrosis triggers osteoclast-mediated bone loss through macrophage-inducible C-type lectin
​雑誌:J Clin Invest 130(9):4811, 2020
2020年12月2日
(WEB開催)
Gli1+細胞はH型血管と結合し、H型血管形成に必要である
​原題:Gli1+ Cells Couple with Type H Vessels and Are Required for Type H Vessel Formation
雑誌:Stem Cell Reports 15 (1): 110, 2020
2020年12月16日
(WEB開催)
頭蓋顎顔面骨修復用途のための石灰化コラーゲン足場への亜鉛の添加
​原題:The inclusion of zinc into mineralized collagen scaffolds for craniofacial bone repair application
雑誌:Acta Biomater 15;93:86-96, 2019
2021年1月13日
(WEB開催)
Runx2陽性のニッチ細胞はIGFシグナルを介してマウス切歯における間葉系組織の恒常性を維持する
​原題:Runx2+ Niche Cells Maintain Incisor Mesenchymal Tissue Homeostasis through IGF Signaling
​雑誌:Cell Rep 32(6):108007, 2020
2021年1月27日
(WEB開催)
骨芽細胞が発現するビタミンD受容体は骨吸収の活性化に必須
原題:The Vitamin D Receptor in Osteoblast-Lineage Cells Is Essential for the Proresorptive Activity of 1α,25(OH)2D3 in Vivo
​雑誌:Endocrinology 161(11): bqaa178, 2020
2021年2月10日
​(WEB開催)
Hタイプ血管はマウス抜歯窩が治癒する間に骨のリモデリングに寄与する
原題:H-type blood vessels participate in alveolar bone remodeling during murine tooth extraction healing
雑誌:Oral Dis 26(5):998-1009, 2020

2021年2月24日
(WEB開催)
活性化された骨格幹細胞による関節軟骨の再生
原題:Articular cartilage regeneration by activated skeletal stem cells
雑誌:Nat Med 26(10):1583-1592, 2020
2021年3月10日
(WEB開催)
破骨細胞由来アポトーシス小体は、骨リモデリングの骨吸収と骨形成を共役する
原題:Osteoclast-derived apoptotic bodies couple bone resorption and formation in bone remodeling
雑誌:Bone Res 9(1):5, 2021
2021年3月24日
(WEB開催)
骨再生における多細胞輸送を可能とするHaversian bone模倣スキャフォールドの3Dプリンティング
原題:3D printing of Haversian bone–mimicking scaffolds for multicellular delivery in bone regeneration
​雑誌:Sci Adv 6(12):eaaz6725, 2020
2020年度 顎骨疾患プロジェクト共催セミナー
日時/演題/講師
1 第461回大学院セミナー(2020年10月13日WEB開催)
演題:骨恒常性を司る骨リモデリング機構の解明
講師:東京医科歯科大学大学院医歯学総合研究科 分子情報伝達学 教授
   中島 友紀 先生

2 第462回大学院セミナー(2020年11月30日WEB開催)
演題:FGF23-Klotho系の新たな知見
講師:東海大学腎内分泌代謝内科 准教授
   駒場 大峰 先生
3 第463回大学院セミナー(2021年1月14日WEB開催)
【キャリアアップシリーズ:基礎系】
演題:キャリアについて,もう一度考えてみませんか?
​講師:Abwiz Bio Inc (San Diego, CA, USA), CEO
   千葉大学医学部客員准教授
   奥村 繁 先生
4 第464回大学院セミナー(2021年2月17日WEB開催)
【キャリアアップシリーズ:臨床系】
演題:なぜ、大学院に入ったのですか、また、学位取得後、何を行いたいのですか?
講師:武田歯科医院院長
   武田 孝之 先生
5 第465回大学院セミナー(2021年3月11日WEB開催)
【キャリアアップシリーズ:大学での臨床、研究、教育】
演題:なぜ小児歯科医を目指し、歯の研究を進めてきたか
講師:九州大学大学院歯学研究院、小児口腔医学分野 教授
​   東北大学大学院歯学研究科、小児発達歯科学分野 教授
   福本 敏 先生
2020年度 研究ブランディング事業大学院研究助成
助成受賞者 一覧
氏名(年次) 講座名 研究課題
中根 咲(3) 歯周病学 歯周炎による歯槽骨吸収における細胞障害性Tリンパ球抗原-4(CTLA-4)の役割の解明
内藤 哲(4) 解剖学 Myostatinは筋-腱接合部において筋幹細胞を腱細胞へ分化させるか? 
重松 正樹(2) 口腔インプラント学 チタン製インプラント生着における抑制性免疫制御機構の関与の解明
岡 弘貢(2) 口腔インプラント学 歯根膜に局在するレプチン受容体陽性細胞の性状解析
松上 大亮(4) 歯周病学 機能性モチーフ修飾自己組織化ペプチドハイドロゲル応用が歯周組織治癒に及ぼす影響
中村 ゆりこ(3) 口腔腫瘍外科学 リキッドバイオプシーで応用可能なGorlin症候群診断遺伝子パネルの開発
中里 晴香(3) 歯内療法学 象牙質形成制御のメカニズムを解析する
2020年度 研究ブランディング事業研究助成
氏名 所属 職種 研究課題
木村 麻記 生理学 講師 硬組織形成細胞におけるcAMP誘発性Ca2+シグナル経路の解明
今村 健太郎 歯周病学  講師  ヒト胎盤由来羊膜・絨毛膜(PAC)膜の応用による歯周組織再生の基礎的研究
喜田 大智 歯周病学 助教 Capnocytophaga ochraceaのIX型分泌機構により分泌されるEPS内タンパク質がバイオフィルム形成に与える影響の解明
吉田 航 歯周病学 レジデント Non-contained型歯周組織欠損に対する中性自己組織化ペプチドとPTHを併用した歯周組織再生の試み

1.         Aoki H, Bizenjima T, Seshima F, Sato M, Irokawa D, Yoshikawa K, Yoshida W, Imamura K, Matsugami D, Kitamura Y, Kita D, Sugito H, Tomita S, Saito A. Periodontal surgery using rhFGF-2 with deproteinized bovine bone mineral or rhFGF-2 alone: 2-year follow-up of a randomized controlled trial. J Clin Periodontol 48:92-100, 2021. doi: 10.1111/jcpe.13385.

2.         Aoki K, Matsunaga S, Ito S, Shibahara T, Nomura T, Matsuzaki H, Abe SYamaguchi A. Persistent bone resorption lacunae on necrotic bone distinguish bisphosphonate-related osteonecrosis of jaw from denosumab-related osteonecrosis. J Bone Miner Metab 2021 Apr 8. doi: 10.1007/s00774-021-01223-4..

3.         Arai Y, Kikuchi Y, Okamoto-Shibayama K, Kokubu E, Shintani S, Ishihara K:  Investigation of the potential regulator proteins associated with the expression of major surface protein and dentilisin in Treponema denticola. J Oral Microbiol. 12: 1829404, 2020. doi: 10.1080/20002297.2020.1829404

4.         Ariizumi D, Sakamoto T, Ishii T, Sueishi K, Nishii Y, Sakamoto Y, Ogata H: Three-dimensional Coordinate System for Hemifacial Microsomia. Plast Reconstr Surg Glob Open. 8:e2761, 2020. doi: 10.1097/GOX.0000000000002761.

5.         Atsushi Nemoto, Yoshihiko Akashi, Kei Nakajima, Katsutoshi Kokubun, Kenichi Sasaki, Takashi Inoue, Kenichi Matsuzaka.:The effects of recombinant human basic fibroblast growth factor on nerve regeneration in a partial defect inferior alveolar nerve model in rabbits. J Oral Maxillofac Surg Med Pathol. 33(3) 348 – 353, 2021.

6.         Azuma T, Sato Y, Ohno T, Azuma M, Kume H: Serum soluble B7-H3 is a prognostic marker for patients with non-muscle-invasive bladder cancer. PLoS One.15:e0243379, 2020. doi: 10.1371/journal.pone.0243379.

7.         Baba A, Masuda K, Hashimoto K, Matsushima S, Yamauchi H, Ikeda K, Yamazaki M, Suzuki T, Ogane S, Kurokawa R, Kurokawa M, Ota Y, Mogami T, Nomura T, Ojiri H: Correlation between the Magnetic Resonance Imaging Features of Squamous Cell Carcinoma of the Buccal Mucosa and Pathological Depth of Invasion. Oral Surg Oral Med Oral Pathol Oral Radiol. 131(5):582-590,2021

8.         Cho KH, Morimoto I, Yamamoto M, Hanada S, Murakami G, Rodríguez-Vázquez JF, Abe S : Fetal development of the human trapezius and sternocleidomastoid muscles. Anatomy & Cell Biology, 53(4):405-410, 2020

9.         Eitoyo Kokubu, Yuichiro Kikuchi, Kazuko Okamoto-Shibayama and Kazuyuki Ishihara. The motility of Treponema denticola is affected from surface proteins. Applied and Environmental Microbiology (投稿中)

10.     Hamba H, Nakamura K, Nikaido T, Tagami J, Muramatsu T. Remineralization of enamel subsurface lesions using toothpaste containing tricalcium phosphate and fluoride: an in vitro µCT analysis. BMC Oral Health 20: 292, 2020. doi: 10.1186/s12903020012861

11.     Hasegawa A, Takahashi AN, Kasahara M, Saso N, Narisawa S, Millán JL, Samura O, Sago H, Okamoto A, Umezawa A: Prenatal enzyme replacement therapy for Akp2-/- mice with lethal hypophosphatasia. Regen Ther, (Submission)

12.     Hashimoto C, Kitamura K, Yamamoto M, Honkura Y, Murakami G, Abe H, Abe S : Auricular cartilage configuration: a histological study using late-stage human fetuses and adult cadavers. The Anatomical Record, 2021. https://doi.org/10.1002/ar.24608

13.     Hinata N, Hussein A, Bando Y, Terakawa T, Murakami G, Yamamoto M, Abe S, Guru K, Fujisawa M : Histological investigation of the female vesicourethral junction and adjacent tissues for nerve-sparing radical cystectomy. Urology, 149:11-167, 2021.

14.     Hiraga C, Yamamoto S, Hashimoto S, Kasahara M, Minamisawa T, Matsumura S, Katakura A, Yajima Y, Nomura T, Shiba K: Pentapartite fractionation of particles in oral fluids by differential centrifugation. Sci Rep, 11(1):3326. doi: 10.1038/s41598-021-82451-6, 2021

15.     Hosoya A, Nazmus S, Takebe H, Fujii S, Seki Y, Mizoguchi T, Shimo T, Iijima M, Irie K.: Stem cell properties of Gli1-positive cells in the periodontal ligament. Journal of Oral Biosciences. 62(4):299-305, 2020

16.     Ichioka H, Miyamori D, Ishikawa N, Bandou R, Idota N, Kondou H, Ikegaya H.:Estimation of cadaveric age by ultrasonography. Diagnostics 10(7):499, 2020  

17.     Ikeda Y, Suzuki T, Saitou H, Ogane S, Hashimoto K, Takano N, Nomura T: Usefulness of fluorescence visualization-guided surgery for early-stage tongue squamous cell carcinoma compared to iodine vital staining. Int J Clin Oncol. 5(9):1604-1611, 2020. DOI: 10.1007/s10147-020-01710-0

18.     Inagaki K, Kikuchi,T, Noguchi T, Mitani A, Naruse K, Matsubara T, Kawanami M, Negishi J, Furuichi Y, Nemoto E, Yamada S, Yoshie H, Tabeta K, Tomita S, Saito A, Katagiri S, Izumi Y, Nitta H, Iwata T, Numabe Y, Yamamoto M, Yoshinari N, Fujita T, Kurihara H, Nishimura F, Nagata T, Yumoto H, Naito T, Noguchi K, Ito K, Murakami S, Nishimura R, Tajima N: A largescale observational study to investigate the current status of diabetic complications and their prevention in Japan (JDCP study 6): baseline dental and oral findings .Diabetol Int 12:52-61, 2021.

19.     Ishii M, Cho KH, Kitamura K, Yamamoto M, Murakami G, Rodríguez-Vázquez JF, Abe S : Development and growth of the craniocervical junction with special reference to topographical relationship between the occipital basion, the anterior arch of atlas, and the odontoid process of axis: a study using human fetuses. The Anatomical Record. 304(2) 353 - 365 2021.

20.     Ishii T, Sueishi K, Nishii Y. The Increase of Maxillary Lateral Expansion Limit by Local Application of Fluvastatin. IJOMS : 20-3 [in peer revier]

21.     Ishikawa N, Yamasawa M, Kitamura K, Kuroda H, Yamamoto H: Survey of dental hygienists' and dental hygienist students' attitudes towards body identification tasks of unidentified human remains. Int J Dent Hyg. 19(1):99-105. 2021.

22.     Izawa K, Okamoto-Shibayama K, Kita D, Tomita S, Saito A, Ishida T, Ohue M, Akiyama Y, Ishihara K: Taxonomic and gene category analyses of subgingival plaques from a group of Japanese individuals with and without periodontitis. Int J Mol Sci (submitted)

23.     Jin ZW, Hayashi S, Murakami G, Rodríguez-Vázquez JF, Jörg Wilting, Abe S : Left/right difference in the course and division of the pulmonary arterial branches in the lung upper lobe: A study using human embryos and early fetuses. Journal of Anatomy, 237(5): 854 - 860 2020.

24.     Kameyama A, Saito A, Haruyama A, Komada T, Sugiyama S, Takahashi T, Muramatsu T. Marginal leakage of endodontic temporary restorative materials around access cavities prepared with pre-endodontic composite build-up: An in vitro study. Materials 13(7). pii: E1700, 2020 doi: 10.3390/ma13071700.

25.     Kasahara M, Matsunaga S, Someya T, Kitamura K, Odaka K, Ishimoto T, Nakano T, Abe S, Hattori M: Micro- and nano-bone analyses of the human mandible coronoid process and tendon-bone entheses. J Biomed Mater Res B Appl Biomater. 108(7):2799-2806. 2020. (doi: 10.1002/jbm.b.34609.).

26.     Kasahara N., Matsunaga S., Yamamoto M., Morita S., Odaka K., Abe S., Yamamoto H.: Comparative study of morphology and distribution of valves in human retromandibular vein. Bull Tokyo Dent Coll. 62(2): 1-8. 2021.

27.     Kasahara YN, Kuraoka M, Posadas HG, Kinoh HH, Maruoka Y, Takahashi AN, Kimura K, Takeda S, Okada T: Dental pulp stem cells can improve muscle dysfunction in animal models of duchenne muscular dystrophy. Stem cell Res, 12(1):78, 2021. doi: 10.1186/s13287-020-02099-3

28.     Kasahara YN, Mizumoto S, Inoue YU, Saka S, Posadas HG, Takahashi AN, Takahashi Y, Hashimoto A, Konishi K, Miyata S, Masuda C, Matsumoto E, Maruoka Y, Yoshizawa T, Tanase T, Inoue T, Yamada S, Nomura Y, Takeda S, Watanabe A, Kosho T, Okada T: Muscle pathophysiology in mouse models of musculocontractural Ehlers-Danlos syndrome due to CHST14 mutations (mcEDS-CHST14), generated through CRISPR/Cas9-mediated genomic editing. Dis Model Mech, (Submission)

29.     Kasahara YN, Posadas HG, Takahashi AN, Mizumoto S, Inoue YU, Inoue T, Nomura Y, Takada S, Yamada S, Kosho T, Okada T: Myopathy associated with dermatan sulfate-deficient decorin in musculocontractural ehlers-danlos syndrome: a mouse model investigation. Front Cell Dev Biol, (submission)

30.     Kasahara, N, Odaka, K, Kitamura, K, Kasahara, M, Yamada, M, Matsunaga, S, Hashimoto M. Analysis of microstructure in capybara’s femur. Jpn J Clin Biomech, 41:271-276, 2020.

31.     Kato K, Ikeda R, Suzuki J, Hirano-Kawamoto A, Kamakura Y, Fujiu-Kurachi M, Hyodo M, Izumi S, Koyama S, Sasaki K, Nakajima J, Karaho T, Kimura Y, Kumai Y, Fujimoto Y, Nito T, Oku Y, Kurosawa H, Kuriyama S, Katori Y. Questionnaire survey on nurses and speech therapists regarding dysphagia rehabilitation in Japan. Auris Nasus Larynx. 2021;48(2):241-247.

32.     Kawakami M, Yasuda H, Nishida D, Katakura A, Mizoguchi T.: Development of a method for the identification of receptor activator of nuclear factor-κ B+ populations in vivo. Journal of Oral Biosciences. 63(1):45-51, 2021

33.     Kim JH, Hayashi S, Yamamoto M, Murakami G, Wilting J, Rodríguez-Vázquez JF : Examination of the Annular Tendon (Annulus of Zinn) as a Common Origin of the Extraocular rectus muscles: 2. Embryological basis of extraocular muscles anomalies. Investigative Ophthalmology & Visual Science, 61(12):5, 2020. https://doi:10.1167/iovs.61.12.5.

34.     Kim JH, Sugai N, Suzuki D, Murakami G, Abe H, Rodríguez-Vázquez JF, Yamamoto M : Paratenon of the cruciate ligaments of the knee: a macroscopic and histological study of human fetuses. Folia Morphologica, 2021. (in press)

35.     Kimura E, Obata T, Kitai S, Ishii T, Sakamoto T, Watanabe M, Watanabe A, Narita M, Nakano Y, Takano N, Sueishi K, Nishii Y: Three-Dimensional Measurements of Pharyngeal Airway in Patients with Unilateral Cleft Lip and Palate. Bull Tokyo Dent Coll. 61:213-219, 2020. doi: 10.2209/tdcpublication.2020-0019.

36.     Kimura M., Mochizuki H., Kono K., Ohyama S., Kuroda H., and Shibukawa Y: Plasma membrane Ca2+-ATPase-mediated dentin formation and mineralization, Biomolecules, in submission

37.     Kimura Y, Ueha R, Furukawa T, Osima F, Fujitani J, Nakajima J, Kaneoka A, Aoyama H, Fujimoto Y and Umezaki T. Sosiety of Swallowing and Dysphagia of Japan: Position statement on dysphagia management during the COVID-10 outbreak: Auris Nasus Larynx. 2020;47(5):715-726. doi: 10.1016/j.anl.2020.07.009.

38.     Kitamura K, Kim JH, Cho KH, Murakam G, Rodríguez-Vázquez JF, Yamamoto H: Regional differences in zygapophysial joint cavities: A histological study of human fetuses. Anat Rec. 304(5):979-990. 2021.

39.     Kitamura K, Yamamoto M, Hirota Y, Sato N, Machida T, Ishikawa N, Yamamoto H, Murakami G, Abe S: Cervical nerve roots and the dural sheath: a histological study using human fetuses near term. Anat Cell Biol. 31;53(4):451-459. 2020.

40.     Kitamura, K., Odaka, K., Kasahara, M., Kasahara, N., Yamada, M., Matsunaga, S. Three-dimensional analysis of growth process in embryonic laryngeal cartilage. Jpn J Clin Biomech, 41:413-418, 2020.

41.     Kobayashi A, Kasahara M, Koshika K, Akiike Y, Matsuura N, Ichinohe T: Remifentanil infusion during desflurane anesthesia reduces tissue blood flow while maintaining blood pressure and tissue oxygen tension in the masseter muscle and mandibular bone marrow. J Vet Med Sci, 83(1):62-68, 2021

42.     Kokubu E, Kikuchi Y, Okamoto-Shibayama K, Ishihara K:  Effect of Treponema denticola infection on epithelial cells. Oral Dis. submitted

43.     Koyachi M, Sugahara K, Odaka K, Matsunaga S, Abe S, Sugimoto M, Katakura A. Accuracy of Le Fort I osteotomy with combined computer-aided design/computer-aided manufacturing technology and mixed reality. Int J Oral Maxillofac Surg.2020 doi: 10.1016/j.ijom.2020.09.026

44.     Kubo, S., Yamaguchi, A., Matsunaga, S. An Analysis of 949 Cases of Condylar Process Fracture of the Mandible. IOSR-JDMS, 19(4):47-53, 2020.DOI: 10.9790/0853-1904134753

45.     Kugimiya Y, Oki T, Ohta M, Ryu M, Kobayashi K, Ueda T: Distribution of lip-seal strength and its relation to oral motor functions. Clin Exp Dent Res (in press)

46.     Kugimiya Y, Watanabe Y, Shirobe M, Motohashi Y, Motokawa K, Edahiro A, Ohara Y, Ryu M, Igarashi K, Hoshino D, Nakajima J, Ueda T, Taniguchi Y, Ogawa T, Maekawa K, Tamaki K, Kuboki T, Kitamura A, Shinkai S, Hirano H. A comparison of colorimetric and visual methods for the assessment of masticatory performance with color-changeable chewing gum in older persons: J Dent Sci. 2021;16(1):380-388. doi: 10.1016/j.jds.2020.08.010.

47.     Kusaba, G., Matsunaga, S., Kitamura, K., Kasahara, M., Shimoo, Y., Abe, S., Nakano, T., Ishimoto, T., Hikita, A., Nojima, K., Nishii, Y. Micro/nanostructural characteristic changes in the mandibles of rats after injection of botulinum neurotoxin. J Hard Tissue Biol, 2021 (in press).

48.     Maekawa K, Ikeuchi T, Shinkai S, Hirano H, Ryu M, Tamaki K, Yatani H, Kuboki T: Number of functional teeth more strongly predicts all-cause mortality than number of present teeth in Japanese older adults. Geriatr Gerontol Int 20:607-614, 2020. doi: 10.1111/ggi.13911

49.     Masami Sumi, Yoshihiko Akashi, Kei Nakajima, Katsutoshi Kokubun, Satoshi Murakami, Kenichi Matsuzaka, Takashi Inoue.:Immunohistochemical study of CK7 and CK17 on metaplastic cells of dentigerous cysts, and RNA expression in cultured odontogenic epithelial cells after centrifugal force.日本口腔検査学会雑誌. 13(1): 3 – 13, 2021.

50.     Matsugami D, Murakami T, Yoshida W, Imamura K, Bizenjima T, Seshima F, Saito A: Treatment with functionalized designer self-assembling peptide hydrogels promotes healing of experimental periodontal defects. J Periodontal Res. 56:162-172, 2021. doi: 10.1111/jre.12807.

51.     Matsunaga S., Odaka K., Kasahara N., Kasahara M., Kitamura K., Yamada M.: Structural characteristics of newly formed osteon-like structure in peri-implant bone. Jpn J Clin Biomech. 41:393-397. 2020.

52.     Miura K, Ohkubo M, Sugiyama T, Tsuiki M, Ishida R: Determination of the Relationships Between intra- and Extraoral Tongue Hardness, Thickness, and Pressure Using Ultrasonic Elastography. Dysphagia. 2020 Sep 1. (in press) doi: 10.1007/s00455-020-10176-1.

53.     Miyamori D, Tanaka Y, Ishikawa N, Kitamura T, Ikegaya H.:Population history in Okinawa based on JC virus and ALDH2 genotypes. Scientific Reports 10(1):7331, 2020

54.     Morikawa T, Shibahara T, Nomura T, Katakura A, Takano M: Non-Invasive Early Detection of Oral Cancers Using Fluorescence Visualization with Optical Instruments. Cancers(Basel). 12(10): 2771,2020. DOI: 10.3390/cancers12102771

55.     Morita N, Onodera S, Nakamura Y, Nakamura T, Takahashi SI, Nomura T, Azuma T.: Keratinocytes from Gorlin Syndrome-induced pluripotent stem cells are resistant against UV radiation. Med Mol Morphol. 12020 Aug 20.  doi: 10.1007/s00795-020-00264-4.

56.     Morita, S., Moriishi, T., Matsunaga, S., Kitamura, K., Abe, S., Yamaguchi, A.: Comparative morphological study of hematopoiesis in bone marrow of Xenopus laevis and mice. Bull Tokyo Dent Coll, 2021 (in press).

57.     Moriyama T, Shibahara T, Takano M, Iwamoto M, Takaki T, Kasahara K, Nomura T, Takano N, Katakura A: Countermeasure and opportunistic screening systems for oral cancer.Oral Oncol. 112:105047, 2021. DOI: 10.1016/j.oraloncology.2020.105047

58.     Nagai N, Homma H, Sakurai A, Takahashi N, Shintani S.: Microbiomes of colored dental biofilms in children with or without severe caries experience. Clin Exp Dent Res. 6: 659-668, 2020. doi: 10.1002/cre2.317.

59.     Nagakura R, Yamamoto M, Jeong J, Hinata N, Katori Y, Chang WJ, Abe S : Switching of Sox9 expression during musculoskeletal system development. Scientific Reports, 10(1):8425, 2020. https://doi.org/10.1038/s41598-020-65339-9

60.     Nakamura K, Hamba H, Miyayoshi Y, Ishizuka H, Muramatsu T. In vitro remineralization of enamel with a solution containing casein and fluoride. Dental Materials Journal (in press)  doi:10.4012/dmj.2020-383 

61.     Nakamura M, Tanaka A, Tasaka A, Yoshinari M, Takemoto S, Yamashita S.: Comparison of retentive forces between telescopic crowns made of poly (ether ether ketone)  and type 4 gold alloy. Dent Mater J.2020 Aug 28. DOI: 10.4012/dmj.2019-298. Online ahead of print.

62.     Nakamura Y., Nakamura M., Kasahara N., Hashimoto M.: Personal identification by superimposition of three-dimensional intraoral models. Bull Tokyo Dent Coll. 61(3): 169-178. 2020.

63.     Nakamura-Takahashi A, Tanase T, Matsunaga S, Shintani S, Abe S, Nitahara-Kasahara Y, Watanabe A, Hirai Y, Okada T, Yamaguchi A, Kasahara M.: High-Level Expression of Alkaline Phosphatase by Adeno-Associated Virus Vector Ameliorates Pathological Bone Structure in a Hypophosphatasia Mouse Model. Calcif Tissue Int. 106: 665-677, 2020. doi: 10.1007/s00223-020-00676-5.

64.     Nango H, Kosuge Y, Sato M, Shibukawa Y, Aono Y, Saigusa T, Ito Y, Ishige K.: Highly Efficient Conversion of Motor Neuron-Like NSC-34 Cells into Functional Motor Neurons by Prostaglandin E 2. Cells. 2020 Jul 21;9(7):1741. doi: 10.3390/cells9071741.

65.     Naoki Shiraishi, Takeshi Onda, Kamichika Hayashi, Kaoru Onidani, Katsuhito Watanabe, Shoichi Sekikawa, Takahiko Shibahara. Heat shock protein 90 as a molecular target for therapy in oral squamous cell carcinoma: Inhibitory effects of 17 DMAG and ganetespib on tumor cells. Oncology Reports 45:448-458,2021

66.     Nishida D, Arai A, Zhao L, Yang M, Nakamichi Y, Horibe K, Hosoya A, Kobayashi Y, Udagawa N, Mizoguchi T.: RANKL/OPG ratio regulates odontoclastogenesis in damaged dental pulp. Scientific Reports. 11:4575. doi: 10.1038/s41598-021-84354-y, 2021

67.     Nomura Y, Morozumi T, Fukuda M, Hanada N, Kakuta E, Kobayashi H, Minabe M, Nakamura T, Nakayama Y, Nishimura F, Noguchi K, Numabe Y, Ogata Y, Saito A, Sato S, Sekino S, Sugano N, Sugaya T, Suzuki F, Takahashi K, Takai H, Takashiba S, Umeda M, Yoshie H, Yoshimura A, Yoshinari N, Nakagawa T: Optimal examination sites for periodontal disease evaluation: applying the item response theory graded response model. J Clin Med 9(11): 3754, 2020. (https://doi.org/10.3390/jcm9113754)

68.     Nomura Y, Morozumi T, Numabe Y, Ogata Y, Nakayama Y, Sugaya T, Nakamura T, Sato S, Takashiba S, Sekino S, Yoshinari N, Hanada N, Sugano N, Fukuda M, Minabe M, Umeda M, Tabeta K, Takahashi K, Noguchi K, Kobayashi H, Takai H, Nishimura F, Suzuki F, Kakuta E, Yoshimura A, Saito A, Nakagawa T: Estimation of the Periodontal Inflamed Surface Area by simple oral examination. J Clin Med 10:723, 2021 (https://doi.org/10.3390/jcm10040723).

69.     Nomura Y, Morozumi T, Saito A, Yoshimura A, Kakuta E, Suzuki F, Nishimura F, Takai H, Kobayashi H, Noguchi K, Takahashi K, Tabeta K, Umeda M, Tabeta K, Umeda M, Minabe M, Fukuda M, Sugano N, Hanada N, Yoshinari N, Sekino S, Takashiba S, Sato S, Nakamura T, Sugaya T, Nakayama Y, Ogata Y, Numabe Y, Nakagawa T: Prospective longitudinal changes in the periodontal inflamed surface area following active periodontal treatment for chronic periodontitis. J Clin Med 10:1165, 2021 (https://doi.org/10.3390/jcm10061165)

70.     Oda Y, Miura T, Mori G, Sasaki H, Ito T, Yoshinari M, Yajima Y.:  Adhesion of streptococci to titanium and zirconia. PLoS One 15(6):e0234524 2020. doi: 10.1371/journal.pone.0234524

71.     Odaka K, Matsunaga S, Kitamura K, Kasahara M, Kasahara N, Yamada M.: 3-dimentional alignment of biological apatite crystallites around dental implant in beagle maxilla. Jpn J Clin Biomech. 41:399-402. 2020

72.     Ofusa W, Yamada Y, Ishida R, Ohkubo M, Higashikawa A, Kimura M., Shibukawa Y: Use of barometric pressure and electromyography measurement techniques to elucidate the mechanisms by which bolus passes from the oral cavity to the oropharynx during swallowing. Physiol. Behav, 226:113115, 2020. doi: 10.1016/j.physbeh.2020.113115

73.     Ogawa Y, Yamamoto M, Sato M, Odaka K, Kasahara M, Hinata N, Sakiyama K, Abe S : Localization of T-cell factor 4 positive fibroblasts and CD206-positive macrophages during skeletal muscle regeneration in mice. Annals of Anatomy, 2021. https://doi.org/10.1016/j.aanat.2021.151694

74.     Ohkubo M, Ueda T, Miura K, Sugito H, Kawaguchi M, Ono K, Seshima F, Morioka T, Uchiyama S, Yoshida M, Yajima Y: Differences in Elderly and Non-Elderly Outpatient Subjective Evaluation of "Easy-to-Eat Meals" after Dental Treatment. Bull Tokyo Dent Coll. Sep 4;61(3):161-168, 2020 doi: 10.2209/tdcpublication.2019-0009. PMID: 32801259

75.     Ohno T, Nakamura T, Nakae S, Morita H, Matsumoto K, Saito H, Takeda K, Okumura K, Azuma T.: TSLP is a negative regulator of RANKL-induced osteoclastogenesis. Biochem Biophys Res Commun. 2020 Sep 24;530(3):508-512. doi: 10.1016/j.bbrc.2020.05.055. Epub 2020 Jun 26.

76.     Okamoto-Shibayama K, Warita T, Kokubu E, Kita D, Kikuchi Y, Ishihara K: Role of the hyalin-like protein in biofilm formation by Capnocytophaga ochracea. Bull Tokyo Dent Coll (in press)

77.     Okamoto-Shibayama K, Yoshida A, Ishihara K: Inhibitory Effect of Resveratrol on Candida albicans Biofilm Formation. Bull Tokyo Dent Coll. 13;62(1):1-6, 2021 doi: 10.2209/tdcpublication.2020-0023.

78.     Okamura, M., Suzuki, T., Oomura, Y., Matsunaga, S., Nomura, T. Effect of bacterial infection on bone quality and structure in osteonecrosis of the jaw by Bisphosphonate (BP) administration. J Hard Tissue Biol, 2021 (in press).

79.     Onodera S, Saito A, Hojo H, Nakamura T, Zujur D, Watanabe K, Morita N, Hasegawa D, Masaki H, Nakauchi H, Nomura T, Shibahara T, Yamaguchi A, Chung UI, Azuma T, Ohba S.: Hedgehog Activation Regulates Human Osteoblastogenesis. Stem Cell Reports. 2020 Jul 14;15(1):125-139. doi: 10.1016/j.stemcr.2020.05.008. Epub 2020 Jun 11.

80.     Ooki A, Onodera S, Saito A, Oguchi A, Murakawa Y, Sakamoto T, Sueishi K, Nishii Y, Azuma T: CAGE-seq analysis of osteoblast derived from cleidocranial dysplasia human induced pluripotent stem cells. Bone. 141:115582, 2020. doi: 10.1016/j.bone.2020.115582. DOI: 10.1016/j.bone.2020.115582.

81.     Ootake T, Ishii T, Watanabe A, Ishizuka Y, Niushimura K, Nagao M, Amano K, Sueishi K, Nishii Y. Effects of mechanical stress and deficiency of dihydrotestosterone or 17β-estradiol on temporomandibular joint osteoarthritis in mice. Osteoarthritis and Cartilage: OAC11166R1 [in peer revier]

82.     Osaka R, Kato H, Hamada Y, Fujimoto Y, Nobuhito Mizusawa N, Watanabe D, Kaneko A:Clinicostatistical analyses of medicationrelated osteonecrosis of the jaws (MRONJ): Evaluation of the treatment method and prognosis. Oral Science International, doi.org/10.1002/osi2.1098, 2020

83.     Oyanagi T, Kim JH, Yamamoto M, Ishii M, Murakami G, Rodríguez-Vázquez JF, Abe S : Topographical anatomy of the tentorium cerebelli and venous confluences in human midterm fetuses. Annals of Anatomy, 234: 151596, 2021 https://doi.org/10.1016/j.aanat.2020.151596

84.     Rodríguez-Vázquez JF, Yamamoto M, Kim JH, Jin ZW, Katori Y, Murakami G : The incudopetrosal joint of the human middle ear: a transient morphology in fetuses. Journal of Anatomy, 237(1):176-187, 2020.

85.     Ryouichi Satou, Haruka Aikawa, Naoki Sugihara, Risk assessment by seasonal variation of well water fluoride in Japan, French-Ukrainian Journal of Chemistry, 8-2,104-112, 2020, doi.org/10.17721/fujcV8I2P104-112

86.     Ryouichi Satou, Sari Oka, Naoki Sugihara, Risk assessment of fluoride daily intake from preference beverage, Journal of Dental Sciences, 16:220-228, 2021, doi. org/10.1016/j.jds.2020.05.023

87.     Ryu M, Ueda T, Sakurai K: An interprofessional approach to the oral hygiene of the elderly inpatients and the perception of the caregivers towards oral health care. Int Dent J (in press) .doi:10.1111/idj.12632

88.     Ryu M., Oki T., Ohta M., Sakurai K., Ueda T. Effect of Lip-seal Resistance Training on Lip-seal Strength in Young Adults. Bull Tokyo Dent Coll (in press)

89.     Sakamoto Y, Sakamoto T, Ishii T, and Kishi K. Assessment of Bioabsorbable Hydroxyapatite for Secondary Bone Grafting in Unilateral Alveolar Clefts, Cleft Palate-Craniofacial Journal, 57(1):114-117, 2020

90.     Sato M, Aoki H, Nakamura T, Onodera S, Yamaguchi A, Saito A, Azuma T. Effects of intermittent treatment with parathyroid hormone (PTH) on osteoblastic differentiation and mineralization of mouse induced pluripotent stem cells in a 3D culture model. J Periodontal Res 55: 734-743, 2020. doi: 10.1111/jre.12762.

91.     Satomi Kamata, Maki Kimura, Sadao Ohyama, Shuichiro Yamashita, Yoshiyuki Shibukawa. Large-conductance Calcium-activated Potassium Channels and Voltage-Dependent Sodium Channels in Human Cementoblasts. Front. Physiol. in PRESS. doi: 10.3389/fphys.2021.634846

92.     Shinohara C,Ito K,Takamatsu K,Ogawa M,Kajii Y,Nohno K,Sugano A,,Funayama SKatakura ANomura T,Inoue MFactors associated with xerostomia in perimenopausal women. J Obstet Gynecol Res(投稿中)

93.     Shiratori T, Tada M, Wataru O, Yamamoto M, Satoh A, Ishikawa T, Yamada Y.: New method of recording the functional activity pattern of the buccinator from the mucosal surface. Physiology and Behavior, 2021. (in press)

94.     Sugahara K, Hiroki BESSHO, Akihiro NISHIYAMA, Yu KOYAMA, Masahide KOYACHI, Tomoaki TOYODA, Kiyohiro KASAHARA, Akira WATANABE, Masayuki TAKANO, Katakura A. The utility of custom-developed tooth extraction simulator - A comparative analysis from beginner to trainer. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 2021;33,43-47

95.     Sugahara K, Koyachi M, Koyama Y, Sugimoto M, Matsunaga S, Odaka K, Abe S, Katakura A : Mixed reality and three dimensional printed models for resection of maxillary tumor: a case report . Quantitative Imaging in Medicine and Surgery, 2021. (in press) (doi: 10.21037/qims-20-597)

96.     Sugahara K, Koyama Y, Koyachi M, Matsunaga S, Odaka K, Kitamura K, Nakajima K, Matsuzaka K, Abe S, Katakura A: Relationship between the immunohistological examination and fluorescence visualization of oral squamous cell carcinoma. Oncol Lett. 20(3):2153-2160. 2020. (doi: 10.3892/ol.2020.11772).

97.     Sugahara K, Matsunaga S, Yamamoto M, Noguchi T, Morita S, Koyachi M, Koyama Y, Koyama T, Kasahara N, Abe S, Katakura A : Retromandibular vein position and course patterns in relation to mandible: anatomical morphologies requiring particular vigilance during sagittal split ramus osteotomy. Anatomy & Cell Biology, 53(4):444-450, 2020(doi: 10.5115/acb.20.236)

98.     Sugahara, K., Koyachi, M., Odaka, K., Matsunaga, S., Katakura, A.: A safe, stable, and convenient three-dimensional device for high Le Fort I osteotomy. Maxillofac Plast Reconstr Surg, 42(1):32, 2020 (doi: 10.1186/s40902-020-00276-1).

99.     Takahashi I, Sakamoto T, Ishii T, and Sueishi K. Three-Dimensional Evaluation of Change in Maxillary Alveolar Arch after Expansion in Unilateral Cleft Lip and Palate Patients. The Bulletin of Tokyo Dental College,61(2):103-120, 2020

100. Takahiro Iwasaki, Takeshi Onda, Hirona Honda, Kamichika Hayashi, Takahiko Shibahara, Takeshi Nomura, Masayuki Takano. Over-expression of PDE5 in Oral Squamous Cell Carcinoma-Effect of Sildenafil Citrate. Anticancer Research (in press)

101. Takako Eguchi, Ryouichi Satou (Corresponding author), Yasuo Miake, Naoki Sugihara, Comparison of Resistance of Dentin to Erosive Acid after Application of Fluoride to Teeth, Journal of Hard Tissue Biology, 29-3;193-202, 2020, doi.org/10.2485/jhtb.29.193

102. Takehana K, Moresco A, Johnson III J, Kasahara M, Kasahara N, Han S: Severe hydroxyapatite deposition disease in binturongs (Arctictis binturong). Veterinary Pathology (in press)

103. Tamiya Y, Hamba H, Mitomo K, Furusawa M, Muramatsu T. High-cholesterol condition promotes apical periodontitis and bone resorption in rats. Journal of Hard Tissue Biology 30(2):199-204, 2021 DOI https://doi.org/10.2485/jhtb.30.199

104. Tasaka A, Okano H, Odaka K, Matsunaga S, Goto T, Abe S, Yamashita Y : Comparison of artificial tooth position in dentures fabricated by heat-curing and additive manufacturing. Australian Dental Journal, 2021. https://doi.org/10.1111/adj.12817

105. Tasaka A, Okano H, Shimizu T, Kato Y, Higuchi S, Yamashita S.: Influence of reinforcement bar on accuracy of removable partial denture framework fabricated by casting with a 3D-printed pattern and selective laser sintering. J Prosthodont Res. 2020 Sep 15. doi: 10.2186/jpr.JPOR_2020_10. Online ahead of print

106. Tashiro A, Sakurai A, Yonezu T, Kumazawa K, Shintani S: Caries and its association with infant feeding and oral health-related behaviors in 18-and 36-months old Japanese children. Bull Tokyo Dent Coll, in press.

107. Tsuboi H, Miyamori D, Ishikawa N, Ichioka H, Ikegaya H.:Relationship between serum prostate-specific antigen and age in cadavers. SAGE Open Medicine, 8:1-7,2020

108. Uchino M, Arima H, Kobayashi H, Nagata J, Yasumura T, Ishii T, Miyazaki H, Sakamoto T, Nojima K, and Sueishi K. Survey on Condition and Orthodontic Treatment of Maxillary Lateral Incisors in Patients with Cleft Lip and Palate. The Bulletin of Tokyo Dental College,61(2):95-102, 2020

109. Watanabe K, Nakamura T, Onodera S, Saito A, Shibahara T, Azuma T.: A novel GNAS-mutated human induced pluripotent stem cell model for understanding GNAS-mutated tumors. Tumour Biol. 2020 Sep;42(9):1010428320962588. doi: 10.1177/1010428320962588.

110. Yamamoto M, Abe H, Hirouchi H, Sato M, Murakami G, Rodríguez-Vázquez JF, Abe S : Development of the cartilaginous connecting apparatuses in the fetal sphenoid, with a focus on the alar process . PLoS One, 2021. (in press)

111. Yamamoto Y, Ryu M, Ueda T, Sasaki Y, Sakurai K: Effect of Chewing an Elastic Appliance on Frontal Lobe Activity. Sci Rep(投稿中)

112. Yang L, Miura T, Kasahara M. Effectively improved 3-dimensional structural stability of atelocollagen-gelatin sponge biomaterial by heat treatment. Dent Mater J (投稿中)

113. Yasumatsu K, Ohkuri T, Yoshida R, Iwata S, Margolskee RF, Ninomiya Y: Sodium-glucose cotransporter 1 as a sugar taste sensor in mouse tongue. Acta Physiol (Oxf). 230(4):e13529, 2020. doi: 10.1111/apha.13529.

114. Yoshihiko Akashi, Atsushi Nemoto, Kei Nakajima, Katsutoshi Kokubun, Satoshi Murakami, Takashi Inoue, Kenichi Matsuzaka.:The effect of fibroblast growth factor 7 on human dental pulp stem cells for differentiation to AQP5-positive and αSMA-positive cells in vitro and in vivo. Clin Exp Dent Res. (in press)

115. Yuuki ONOSE, Seitaro SUZUKI, Koichi YOSHINO, Yoichi ISHIZUKA, Ryouichi SATOU, Hideyuki KAMIJYO, Naoki SUGIHARA: Relationship between oral symptoms during diving work and preventative dental visits in Japanese male occupational divers. Industrial Health. 58:238-245, 2020. doi.org/10.2486/indhealth.2019-0076

116. Zhaoa L, Ito S, Arai A, Udagawa N, Horibe K, Hara M, Nishida D, Hosoya A, Masuko R, Okabe K, Shin M, Li X, Matsuo K, Abe S, Matsunaga S, Kobayashi Y, Kagami H, Mizoguchi T.: Odontoblast death drives cell-rich zone-derived dental tissue regeneration. Bone. 2021, in press.